The role of natural killer cells in autoimmune diseases
Natural killer (NK) cells, the large granular lymphocytes differentiated from the common
lymphoid progenitors, were discovered in early 1970's. They are members of innate …
lymphoid progenitors, were discovered in early 1970's. They are members of innate …
Clinical trials with mesenchymal stem cells: an update
T Squillaro, G Peluso, U Galderisi - Cell transplantation, 2016 - journals.sagepub.com
In the last year, the promising features of mesenchymal stem cells (MSCs), including their
regenerative properties and ability to differentiate into diverse cell lineages, have generated …
regenerative properties and ability to differentiate into diverse cell lineages, have generated …
Mast cell function: a new vision of an old cell
Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …
effectors of allergy. It has been only in the past two decades that mast cells have gained …
Single-cell mass cytometry reveals distinct populations of brain myeloid cells in mouse neuroinflammation and neurodegeneration models
Neuroinflammation and neurodegeneration may represent two poles of brain pathology.
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …
Brain myeloid cells, particularly microglia, play key roles in these conditions. We employed …
Reviewing the significance of blood–brain barrier disruption in multiple sclerosis pathology and treatment
The disruption of blood–brain barrier (BBB) for multiple sclerosis (MS) pathogenesis has a
double effect: early on during the onset of the immune attack and later for the CNS self …
double effect: early on during the onset of the immune attack and later for the CNS self …
Mitochondrial dysfunction and multiple sclerosis
IP Barcelos, RM Troxell, JS Graves - Biology, 2019 - mdpi.com
In recent years, several studies have examined the potential associations between
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …
mitochondrial dysfunction and neurodegenerative diseases such as multiple sclerosis (MS) …
Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
D Karussis, C Karageorgiou… - Archives of …, 2010 - jamanetwork.com
Objective To evaluate the feasibility, safety, and immunological effects of intrathecal and
intravenous administration of autologous mesenchymal stem cells (MSCs)(also …
intravenous administration of autologous mesenchymal stem cells (MSCs)(also …
The diagnosis of multiple sclerosis and the various related demyelinating syndromes: a critical review
D Karussis - Journal of autoimmunity, 2014 - Elsevier
Multiple sclerosis (MS), is a chronic disease of the central nervous system (CNS)
characterized by loss of motor and sensory function, that results from immune-mediated …
characterized by loss of motor and sensory function, that results from immune-mediated …
Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis
D Fitzner, M Schnaars, D Van Rossum… - Journal of cell …, 2011 - journals.biologists.com
The transfer of antigens from oligodendrocytes to immune cells has been implicated in the
pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small …
pathogenesis of autoimmune diseases. Here, we show that oligodendrocytes secrete small …
Multiple sclerosis: an immune or neurodegenerative disorder?
BD Trapp, KA Nave - Annu. Rev. Neurosci., 2008 - annualreviews.org
Multiple sclerosis (MS) is an inflammatory-mediated demyelinating disease of the human
central nervous system. The clinical disease course is variable, usually starts with reversible …
central nervous system. The clinical disease course is variable, usually starts with reversible …