Considering how biological sex impacts immune responses and COVID-19 outcomes
A male bias in mortality has emerged in the COVID-19 pandemic, which is consistent with
the pathogenesis of other viral infections. Biological sex differences may manifest …
the pathogenesis of other viral infections. Biological sex differences may manifest …
The impact of the Fungus-Host-Microbiota interplay upon Candida albicans infections: current knowledge and new perspectives
C d'Enfert, AK Kaune, LR Alaban… - FEMS microbiology …, 2021 - academic.oup.com
Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …
Sexual-dimorphism in human immune system aging
EJ Márquez, C Chung, R Marches, RJ Rossi… - Nature …, 2020 - nature.com
Differences in immune function and responses contribute to health-and life-span disparities
between sexes. However, the role of sex in immune system aging is not well understood …
between sexes. However, the role of sex in immune system aging is not well understood …
Immune system adaptation during gender-affirming testosterone treatment
Infectious, inflammatory and autoimmune conditions present differently in males and
females. SARS-CoV-2 infection in naive males is associated with increased risk of death …
females. SARS-CoV-2 infection in naive males is associated with increased risk of death …
Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
Smoking changes adaptive immunity with persistent effects
Individuals differ widely in their immune responses, with age, sex and genetic factors having
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
major roles in this inherent variability,,,,–. However, the variables that drive such differences …
Impaired NLRP3 inflammasome activation/pyroptosis leads to robust inflammatory cell death via caspase-8/RIPK3 during coronavirus infection
Coronaviruses have caused several zoonotic infections in the past two decades, leading to
significant morbidity and mortality globally. Balanced regulation of cell death and …
significant morbidity and mortality globally. Balanced regulation of cell death and …
Dissecting human population variation in single-cell responses to SARS-CoV-2
Humans display substantial interindividual clinical variability after SARS-CoV-2 infection,–,
the genetic and immunological basis of which has begun to be deciphered. However, the …
the genetic and immunological basis of which has begun to be deciphered. However, the …
Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies
GE Thorlacius, A Björk… - Nature Reviews …, 2023 - nature.com
In primary Sjögren syndrome (pSS), chronic inflammation of exocrine glands results in tissue
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
destruction and sicca symptoms, primarily of the mouth and eyes. Fatigue, arthralgia and …
Sex and gender differences in bacterial infections
SP Dias, MC Brouwer, D van de Beek - Infection and Immunity, 2022 - Am Soc Microbiol
There is a growing awareness of the importance of sex and gender in medicine and
research. Women typically have stronger immune responses to self and foreign antigens …
research. Women typically have stronger immune responses to self and foreign antigens …