Fundamentals of redox regulation in biology

H Sies, RJ Mailloux, U Jakob - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

Oxidative stress and antioxidant metabolism under adverse environmental conditions: a review

P García-Caparrós, L De Filippis, A Gul… - The Botanical …, 2021 - Springer
Reactive oxygen species (ROS) originate as a natural byproduct in standard metabolism of
oxygen activities. The principal sites of ROS generation in the cell are apoplast …

[HTML][HTML] Short-chain fatty acids as modulators of redox signaling in health and disease

C González-Bosch, E Boorman, PA Zunszain… - Redox biology, 2021 - Elsevier
Short-chain fatty acids (SCFAs), produced by colonic bacteria and obtained from the diet,
have been linked to beneficial effects on human health associated with their metabolic and …

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

J Saleh, C Peyssonnaux, KK Singh, M Edeas - Mitochondrion, 2020 - Elsevier
The COVID-19 pandemic caused by the coronavirus (SARS-CoV-2) has taken the world by
surprise into a major crisis of overwhelming morbidity and mortality. This highly infectious …

Oxidative stress and redox-modulating therapeutics in inflammatory bowel disease

AR Bourgonje, M Feelisch, KN Faber, A Pasch… - Trends in molecular …, 2020 - cell.com
Inflammatory bowel disease (IBD) is associated with the production of reactive species that
target cysteine redox switches in proteins, thereby affecting gene regulation, DNA damage …

[HTML][HTML] Oxidative eustress: On constant alert for redox homeostasis

H Sies - Redox Biology, 2021 - Elsevier
In the open metabolic system, redox-related signaling requires continuous monitoring and
fine-tuning of the steady-state redox set point. The ongoing oxidative metabolism is a …

The role of ROS in tumor infiltrating immune cells and cancer immunotherapy

R Shah, B Ibis, M Kashyap, VA Boussiotis - Metabolism, 2024 - Elsevier
Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed
intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and …

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

M Edeas, J Saleh, C Peyssonnaux - International Journal of Infectious …, 2020 - Elsevier
Abstract The coronavirus 2 (SARS-CoV-2) pandemic is viciously spreading through the
continents with rapidly increasing mortality rates. Current management of COVID-19 is …