Protease propeptide structures, mechanisms of activation, and functions
L Boon, E Ugarte-Berzal, J Vandooren… - Critical Reviews in …, 2020 - Taylor & Francis
Proteases are a diverse group of hydrolytic enzymes, ranging from single-domain catalytic
molecules to sophisticated multi-functional macromolecules. Human proteases are divided …
molecules to sophisticated multi-functional macromolecules. Human proteases are divided …
Activation and regulation of caspase-6 and its role in neurodegenerative diseases
Caspases, a family of cysteine proteases, are major mediators of apoptosis and
inflammation. Caspase-6 is classified as an apoptotic effector, and it mediates nuclear …
inflammation. Caspase-6 is classified as an apoptotic effector, and it mediates nuclear …
Small molecule active site directed tools for studying human caspases
Caspases are proteases of clan CD and were described for the first time more than two
decades ago. They play critical roles in the control of regulated cell death pathways …
decades ago. They play critical roles in the control of regulated cell death pathways …
Comparative structural analysis of the caspase family with other clan CD cysteine peptidases
Clan CD forms a structural group of cysteine peptidases, containing seven individual
families and two subfamilies of structurally related enzymes. Historically, it is most notable …
families and two subfamilies of structurally related enzymes. Historically, it is most notable …
Thioredoxin system as a gatekeeper in caspase-6 activation and nuclear lamina integrity: Implications for Alzheimer's disease
Recent reports in pathophysiology of neurodegenerative diseases (ND) have linked nuclear
lamina degradation/deficits to neuronal cell death. Lamin-B1 damage is specifically involved …
lamina degradation/deficits to neuronal cell death. Lamin-B1 damage is specifically involved …
Palmitoylation of caspase-6 by HIP14 regulates its activation
Abstract Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal
apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease …
apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease …
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions
Caspase-6 is critical to the neurodegenerative pathways of Alzheimer's, Huntington's, and
Parkinson's diseases and has been identified as a potential molecular target for treatment of …
Parkinson's diseases and has been identified as a potential molecular target for treatment of …
Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis
DJ MacPherson, CL Mills, MJ Ondrechen… - Journal of Biological …, 2019 - ASBMB
Caspases are cysteine–aspartic proteases involved in the regulation of programmed cell
death (apoptosis) and a number of other biological processes. Despite overall similarities in …
death (apoptosis) and a number of other biological processes. Despite overall similarities in …
Caspase-6 undergoes a distinct helix-strand interconversion upon substrate binding
Caspases are cysteine aspartate proteases that are major players in key cellular processes,
including apoptosis and inflammation. Specifically, caspase-6 has also been implicated in …
including apoptosis and inflammation. Specifically, caspase-6 has also been implicated in …
Hydrogen-bond-driven supramolecular helical assembly of a coumarin-substituted phthalonitrile derivative: synthesis and in vitro anticancer activity against colorectal …
Phthalonitrile derivatives are generally reported to crystallize in space groups P21/c and P1
in the literature. In this study, 7-hydroxy-4, 8-dimethyl-3-pentylcoumarin (2) and its …
in the literature. In this study, 7-hydroxy-4, 8-dimethyl-3-pentylcoumarin (2) and its …