The discovery of Suv39h1, the first SET domain-containing histone lysine methyltransferase
(HKMT), was reported in 2000. Since then, research on histone methylation has progressed …

Mammalian embryonic development is a tightly regulated process that, from a single zygote,
produces a large number of cell types with hugely divergent functions. Distinct cellular …

Post-translational modifications of DNA and histones are epigenetic mechanisms, which
affect the chromatin structure, ultimately leading to gene expression changes. A number of …

Naive CD4+ T lymphocytes initially undergo antigen-specific activation to promote a broad-
spectrum response before adopting bespoke cytokine expression profiles shaped by …

Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase
1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD) …

Type 2 innate lymphoid cells (ILC2 cells) participate in host defense against helminth
parasites and in allergic inflammation. Given their functional relatedness to type 2 helper T …

Lysine methylation of histone and non-histone substrates by the methyltransferase G9a is
mostly associated with transcriptional repression. Recent studies, however, have highlighted …

Methylation of nonhistone proteins is emerging as a regulatory mechanism to control protein
function. Set7 (Setd7) is a SET-domain-containing lysine methyltransferase that methylates …

Protein methyltransferases (PMTs) comprise a major class of epigenetic regulatory enzymes
with therapeutic relevance. Here we present a collection of chemical probes and associated …

Cardiac hypertrophic growth in response to pathological cues is associated with
reexpression of fetal genes and decreased cardiac function and is often a precursor to heart …