The practice of polypharmacology is not a new concept but the approaches which are being
adopted for administering the two or more drugs together are varied from time to time …

Malaria, in particular infection with P. falciparum (the most lethal of the human malaria
parasite species, responsible for nearly one million deaths every year), is one of the most …

The application of quinoline-based compounds for the treatment of malaria infections is
hampered by drug resistance. Drug resistance has led to the combination of quinolines with …

The nuclear receptor, Nurr1, is critical for both the development and maintenance of
midbrain dopamine neurons, representing a promising molecular target for Parkinson's …

Pyridine and pyrimidine derivatives have received great interest in recent pharmacological
research, being effective in the treatment of various malignancies, such as myeloid …

The resistance of malaria parasites to existing drugs carries on growing and progressively
limiting our ability to manage this severe disease and finally lead to a massive global health …

The development of an efficient strategy for facile access to quinoline-based bis-
heterocycles holds paramount importance in medicinal chemistry. Herein, we describe a …

Thymol and carvacrol are well known antioxidants found in the extract of the plants of thyme
species. The Schiff bases of 2-iso-propyl-5-methyl-phenol (thymol/1a), 2-tert-butyl-5-methyl …

Hybrid molecules have become a well-established and powerful biologically relevant
heterocycles. They constitute a core structure due to their widespread use in pharmaceutical …

Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack
of effective treatments. Here we are focusing on the development of a novel anti-malarial …