Immunoglobulin G (IgG) antibodies are a critical component of the adaptive immune system,
binding to and neutralizing pathogens and other foreign substances. Recent advances in …

Tripartite motif containing-21 (TRIM21) is a cytosolic ubiquitin ligase and antibody receptor
that provides a last line of defense against invading viruses. It does so by acting as a sensor …

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared
to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses …

Vaccinations against SARS-CoV-2 reduce the risk of develo** serious COVID-19 disease.
Monitoring spike-specific IgG subclass levels after vaccinations may provide additional …

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

Antibody dependent cellular cytotoxicity (ADCC) is an Fc-dependent effector function of IgG
important for anti-viral immunity and anti-tumor therapies. NK-cell mediated ADCC is mainly …

Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least
inflammatory, in part because it poorly activates the complement system. Regardless, in …

Monoclonal antibodies (mAbs) that efficiently neutralize SARS-CoV-2 have been developed
at an unprecedented speed. Notwithstanding, there is a vague understanding of the various …

Immunoglobulin M (IgM) is the most ancient of the five isotypes of immunoglobulin (Ig)
molecules and serves as the first line of defence against pathogens. Here, we use cryo-EM …

The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing
the body surfaces and is involved in many key aspects of human physiology, while an …