Medulloblastoma
Medulloblastoma (MB) comprises a biologically heterogeneous group of embryonal tumours
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
of the cerebellum. Four subgroups of MB have been described (WNT, sonic hedgehog …
Retinitis pigmentosa: progress in molecular pathology and biotherapeutical strategies
W Liu, S Liu, P Li, K Yao - International Journal of Molecular Sciences, 2022 - mdpi.com
Retinitis pigmentosa (RP) is genetically heterogeneous retinopathy caused by
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …
photoreceptor cell death and retinal pigment epithelial atrophy that eventually results in …
Unified rhombic lip origins of group 3 and group 4 medulloblastoma
Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …
biologically distinct subgroups, suggesting that a personalized approach to therapy would …
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma
Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
oncogenic gene expression, evolution of drug resistance and poor patient outcomes …
Modeling medulloblastoma in vivo and with human cerebellar organoids
C Ballabio, M Anderle, M Gianesello, C Lago… - Nature …, 2020 - nature.com
Medulloblastoma (MB) is the most common malignant brain tumor in children and among
the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient …
the subtypes, Group 3 MB has the worst outcome. Here, we perform an in vivo, patient …
Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma
Background Medulloblastoma (MB) is a heterogeneous disease in which neoplastic cells
and associated immune cells contribute to disease progression. We aimed to determine the …
and associated immune cells contribute to disease progression. We aimed to determine the …
Medulloblastoma group 3 and 4 tumors comprise a clinically and biologically significant expression continuum reflecting human cerebellar development
Medulloblastoma is currently subclassified into distinct DNA methylation
subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing (RNA …
subgroups/subtypes with particular clinico-molecular features. Using RNA sequencing (RNA …
Chromatin landscapes reveal developmentally encoded transcriptional states that define human glioblastoma
Glioblastoma is an incurable brain cancer characterized by high genetic and pathological
heterogeneity. Here, we mapped active chromatin landscapes with gene expression, whole …
heterogeneity. Here, we mapped active chromatin landscapes with gene expression, whole …
Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability
MYC-driven medulloblastomas are highly aggressive childhood brain tumors, however, the
molecular and genetic events triggering MYC amplification and malignant transformation …
molecular and genetic events triggering MYC amplification and malignant transformation …
Core transcriptional regulatory circuitries in cancer
Y Chen, L Xu, RYT Lin, M Müschen, HP Koeffler - Oncogene, 2020 - nature.com
Transcription factors (TFs) coordinate the on-and-off states of gene expression typically in a
combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed …
combinatorial fashion. Studies from embryonic stem cells and other cell types have revealed …