The importance of EZH2 as a key methyltransferase has been well documented
theoretically. Practically, the first EZH2 inhibitor Tazemetostat (EPZ6438), was approved by …

The cell division cycle-associated protein (CDCA) family is important in regulating cell
division. High CDCA expression is significantly linked to tumor development. This review …

DNA repair dysregulation is a key driver of cancer development. Understanding the
molecular mechanisms underlying DNA repair dysregulation in cancer cells is crucial for …

Glioblastoma (GBM) is the most malignant brain cancer and one of the leading causes of
cancer-related death globally. So, identifying potential molecular signatures and associated …

As histone modification enzymes, EZH2 mediates H3K27 trimethylation (H3K27me3),
whereas LSD1 removes methyl groups from H3K4me1/2 and H3K9me1/2. Synergistic …

Background: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of
mitosis, has been identified as a prospective prognostic biomarker in several cancer types …

Up to 18% of cancer-related deaths worldwide are attributed to lung tumor and global
burden of this type of cancer is ascending. Different factors are responsible for development …

The emerging data compiled during the past five years on 3-deazaneplanocin (DZNep)
provide compelling evidence to reevaluate this drug as a better alternative over the specific …

Background Despite the recent progress of therapeutic strategies in treating prostate cancer
(PCa), the majority of patients still eventually relapse, experiencing dismal outcomes …

The enhancer of zeste homolog 2 (EZH2) is a catalytic component of Polycomb repressive
complex 2 (PRC2) mediating the methylation of histone 3 lysine 27 (H3K27me3) and hence …