A conceptual framework for understanding phase separation and addressing open questions and challenges
Macromolecular phase separation is being recognized for its potential importance and
relevance as a driver of spatial organization within cells. Here, we describe a framework …
relevance as a driver of spatial organization within cells. Here, we describe a framework …
Coacervate droplets for synthetic cells
The design and construction of synthetic cells–human‐made microcompartments that mimic
features of living cells–have experienced a real boom in the past decade. While many efforts …
features of living cells–have experienced a real boom in the past decade. While many efforts …
Phase separation in transcription factor dynamics and chromatin organization
Studies over the past decade have highlighted the key role of liquid–liquid phase separation
in cellular organization and function. Dynamic compartmentalization of transcription factors …
in cellular organization and function. Dynamic compartmentalization of transcription factors …
Liquid-like VASP condensates drive actin polymerization and dynamic bundling
K Graham, A Chandrasekaran, L Wang, A Ladak… - Nature physics, 2023 - nature.com
The organisation of actin filaments into bundles is required for cellular processes such as
motility, morphogenesis and cell division. A network of actin-binding proteins, some of which …
motility, morphogenesis and cell division. A network of actin-binding proteins, some of which …
Liquid–liquid crystalline phase separation in biomolecular solutions
Liquid–liquid phase separation (LLPS) and liquid crystalline (LC) ordering are ubiquitous
phenomena in nature, in a variety of biomolecular solutions. Here, we review instances in …
phenomena in nature, in a variety of biomolecular solutions. Here, we review instances in …
[HTML][HTML] Sha** synthetic cells through cytoskeleton-condensate-membrane interactions
Constructing synthetic cells is fascinating both from the standpoints of understanding cellular
machinery and develo** bioinspired materials for targeted applications. The ability to …
machinery and develo** bioinspired materials for targeted applications. The ability to …
Motor crosslinking augments elasticity in active nematics
In active materials, uncoordinated internal stresses lead to emergent long-range flows. An
understanding of how the behavior of active materials depends on mesoscopic …
understanding of how the behavior of active materials depends on mesoscopic …
The effect of ion shape and concentration on tunable wetting of water droplets on graphite surfaces
A Verduzco, S Meng - Physics of Fluids, 2023 - pubs.aip.org
We study the wetting behaviors of aqueous NaCl and NaNO3 electrolyte nano-droplets on
graphite surfaces by molecular dynamics simulations. Despite the same ion charge and …
graphite surfaces by molecular dynamics simulations. Despite the same ion charge and …
Structure of nematic tactoids of hard rods
A Kuhnhold, P van der Schoot - The Journal of Chemical Physics, 2022 - pubs.aip.org
We study by means of Monte Carlo simulations the internal structure of nematic droplets or
tactoids formed by hard, rod-like particles in a gas of spherical ghost particles that act as …
tactoids formed by hard, rod-like particles in a gas of spherical ghost particles that act as …
[HTML][HTML] Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion
During cytokinesis, a contractile ring consisting of unbranched filamentous actin (F-actin)
and myosin II constricts at the cell equator. Unbranched F-actin is generated by formin, and …
and myosin II constricts at the cell equator. Unbranched F-actin is generated by formin, and …