Immunity and inflammation are key elements of the pathobiology of stroke, a devastating
illness second only to cardiac ischemia as a cause of death worldwide. The immune system …

Stroke remains a leading cause of adult disability. Some degree of spontaneous behavioral
recovery is usually seen in the weeks after stroke onset. Variability in recovery is substantial …

In the adult mammalian brain, neurogenesis from neural stem/progenitor cells continues in
two regions: the subgranular zone in the dentate gyrus and the subventricular zone lining …

A bulk of experimental evidence supports the idea that the stroke-damaged adult brain
makes an attempt to repair itself by producing new neurons also in areas where …

Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune
system and neuroplasticity mechanisms under both physiological conditions and …

Objective: To describe the role of adhesion molecules in ischemic stroke. Methods: A
PubMed search of literature pertaining to this study was conducted in April 2008 using …

It has been nearly a century since the early description of microglia by Rio-Hortega; since
then many more biological and pathological features of microglia have been recognized …

Experimental and clinical data have demonstrated that activating the immune system in the
CNS can be destructive. However, other studies have shown that enhancing an immune …

Immunity refers to the body's defense mechanism to protect itself against illness or to
produce antibodies against pathogens. Senescence is a cellular phenomenon that …

A wide range of therapies shows promise for improving poststroke brain repair. Insights into
the neurobiology of brain repair after stroke in animals and in humans continue to accrue …