Abstract Background The Wnt signaling pathway is a complex network of protein interactions
that functions most commonly in embryonic development and cancer, but is also involved in …

Colorectal cancer (CRC) is one of the most common malignant tumor types occurring in the
digestive system. The incidence of CRC has exhibits yearly increases and the mortality rate …

Chemotherapeutics occupy a pivotal role in the medication of different types of cancers, but
the prevalence and mortality rates of cancer remain high. The drug resistance and low …

Cancer, the second cause of death worldwide, is characterized by several common criteria,
known as the “cancer hallmarks” such as unrestrained cell proliferation, cell death …

Since their discovery, cancer stem cells have become a hot topic in cancer therapy research.
These cells possess stem cell-like self-renewal and differentiation capacities and are …

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the world's
fourth most deadly cancer. CRC, as a genetic susceptible disease, faces significant …

Canonical WNT signaling is an important developmental pathway that has attracted
increased attention for anticancer drug discovery. From the production and secretion of WNT …

Deregulation of transcription factors is critical to hallmarks of cancer. Genetic mutations,
gene fusions, amplifications or deletions, epigenetic alternations, and aberrant post …

A practical protocol for the synthesis of 4‐sulfonyl pyrazoles via the reactions of readily
available N, N‐dimethyl enaminones and sulfonyl hydrazines has been developed via the …

In continuation of our previous work on cancer and inflammation, 15 novel pyrazole–
pyrazoline hybrids (WSPP1–15) were synthesized and fully characterized. The formation of …