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Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Autophagy and skin wound healing
H Ren, F Zhao, Q Zhang, X Huang, Z Wang - Burns & trauma, 2022 - academic.oup.com
Autophagy is a lysosome-dependent, self-renewal mechanism that can degrade and recycle
cellular components in eukaryotic cells to maintain the stability of the intracellular …
cellular components in eukaryotic cells to maintain the stability of the intracellular …
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …
Guanylate-binding proteins convert cytosolic bacteria into caspase-4 signaling platforms
Bacterial lipopolysaccharide triggers human caspase-4 (murine caspase-11) to cleave
gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the …
gasdermin-D and induce pyroptotic cell death. How lipopolysaccharide sequestered in the …
Crosstalk between ER stress, autophagy and inflammation
The endoplasmic reticulum (ER) is not only responsible for protein synthesis and folding but
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
also plays a critical role in sensing cellular stress and maintaining cellular homeostasis …
Autophagy induction promoted by m6A reader YTHDF3 through translation upregulation of FOXO3 mRNA
WC Hao, MJ Dian, Y Zhou, QL Zhong, WQ Pang… - Nature …, 2022 - nature.com
Autophagy is crucial for maintaining cellular energy homeostasis and for cells to adapt to
nutrient deficiency, and nutrient sensors regulating autophagy have been reported …
nutrient deficiency, and nutrient sensors regulating autophagy have been reported …
Decoy exosomes provide protection against bacterial toxins
The production of pore-forming toxins that disrupt the plasma membrane of host cells is a
common virulence strategy for bacterial pathogens such as methicillin-resistant …
common virulence strategy for bacterial pathogens such as methicillin-resistant …
TAK1-TABs complex: a central signalosome in inflammatory responses
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1) is a member of the MAPK
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …
kinase kinase (MAPKKK) family and has been implicated in the regulation of a wide range of …
[HTML][HTML] Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate
immune responses but may still be vulnerable to some. Here, we systematically analyze the …
immune responses but may still be vulnerable to some. Here, we systematically analyze the …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …
Since then, this topic has received increasing attention, and many scientists have entered …