Cancer is one of the leading causes of death and morbidity with a complex pathophysiology.
Traditional cancer therapies include chemotherapy, radiation therapy, targeted therapy, and …

Photothermal therapy (PTT) has received increasing attention due to its high selectivity, non-
invasiveness, negligible drug resistance, oxygen independence, and minimal side effects. In …

Emerging therapeutics that utilize RNA interference (RNAi) have the potential to treat broad
classes of diseases due to their ability to reversibly silence target genes. In August 2018, the …

Nanoparticles are generally defined as any particulate material for which at least one
dimension lies in the range of 1− 100 nm. 1− 3 They can exist in various shapes, such as …

Efficient genome editing with Cas9–sgRNA in vivo has required the use of viral delivery
systems, which have limitations for clinical applications. Translational efforts to develop …

Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

BRD4, a bromodomain and extraterminal domain (BET) family member, is an attractive
target in multiple pathological settings, particularly cancer. While BRD4 inhibitors have …

Gene-based therapy is the intentional modulation of gene expression in specific cells to treat
pathological conditions. This modulation is accomplished by introducing exogenous nucleic …

Loss of cell cycle control is characteristic of tumorigenesis. The protein p21 is the founding
member of cyclin-dependent kinase inhibitors and an important versatile cell cycle protein …

Infectious diseases are the leading cause of mortality worldwide, with viruses in particular
making global impact on healthcare and socioeconomic development. In addition, the rapid …