The identification of RNAs that are not translated into proteins was an important
breakthrough, defining the diversity of molecules involved in eukaryotic regulation of gene …

Abstract Background Long non-coding RNAs (lncRNAs) have a size of more than 200 bp
and are known to regulate a host of crucial cellular processes like proliferation …

The spliced alignment of expressed sequence data to genomic sequence has proven a key
tool in the comprehensive annotation of genes in eukaryotic genomes. A novel algorithm …

Motivation: We introduce gmap, a standalone program for map** and aligning cDNA
sequences to a genome. The program maps and aligns a single sequence with minimal …

To better understand the role of alternative splicing, we conducted a large-scale analysis of
reliable alternative isoforms of known human genes. Each isoform was classified according …

Studies of nonsense-mediated mRNA decay in mammalian cells have proffered unforeseen
insights into changes in mRNA–protein interactions throughout the lifetime of an mRNA …

Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes
have alternative splice forms, suggesting that alternative splicing is one of the most …

Alternative splicing is one of the most important mechanisms to generate a large number of
mRNA and protein isoforms from the surprisingly low number of human genes. Unlike …

The kidney plays a vital role in the body's defense against potentially toxic xenobiotics and
metabolic waste products through elimination pathways. In particular, secretory transporters …

Background Recently, genomic sequencing efforts were finished for Oryza sativa (cultivated
rice) and Arabidopsis thaliana (Arabidopsis). Additionally, these two plant species have …