Neurogranin (Ng) is a small protein usually expressed in granule-like structures in pyramidal
cells of the hippocampus and cortex. However, its clinical value is not fully clear so far …

Objective Widespread implementation of cerebrospinal fluid (CSF) biomarkers of
Alzheimer's disease (AD) in clinical settings requires improved accuracy for diagnosis of …

Auditory experience drives neural circuit refinement during windows of heightened brain
plasticity, but little is known about the genetic regulation of this developmental process. The …

Compared with other mammalian species, humans are particularly susceptible to tau-
mediated neurodegenerative disorders. Differential interactions of the tau protein with other …

Abstract Background Neurogranin (Ng), encoded by the schizophrenia risk gene NRGN, is a
calmodulin-binding protein enriched in the postsynaptic compartments, and its expression is …

Identifying novel treatments that facilitate extinction learning could enhance cue-exposure
therapy and reduce high relapse rates in alcoholics. Activation of mGlu5 receptors in the …

Long-lasting forms of long-term potentiation (LTP) represent one of the major cellular
mechanisms underlying learning and memory. One of the fundamental questions in the field …

Progressive cognitive declines are the main clinical symptoms of Alzheimer's disease (AD).
Cognitive impairment in AD is directly correlated with amyloid beta (Aβ)-mediated synaptic …

Experience-dependent synapse refinement is essential for functional optimization of neural
circuits. However, how sensory experience sculpts excitatory synaptic transmission is poorly …

Both in utero exposure to maternal immune activation and cannabis use during adolescence
have been associated with increased risk for the development of schizophrenia; however …