Endosomes are central protein-sorting stations at the crossroads of numerous membrane
trafficking pathways in all eukaryotes. They have a key role in protein homeostasis and …

The retromer complex has a well-established role in endosomal protein sorting, being
necessary for maintaining the dynamic localisation of hundreds of membrane proteins that …

Abstract During endosomal recycling, Sorting Nexin 17 (SNX17) facilitates the transport of
numerous membrane cargo proteins by tethering them to the Retriever complex. Despite its …

The molecular events that determine the recycling versus degradation fates of internalized
membrane proteins remain poorly understood. Two of the three members of the SNX-FERM …

Recycling of membrane proteins enables the reuse of receptors, ion channels and
transporters. A key component of the recycling machinery is the endosomal sorting complex …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the most
common cause of dementia. The pathogenesis of AD still remains unclear, including two …

Protein homeostasis is maintained by removing misfolded, damaged, or excess proteins and
damaged organelles from the cell by three major pathways; the ubiquitin-proteasome …

Coat complexes coordinate cargo recognition through cargo adaptors with biogenesis of
transport carriers during integral membrane protein trafficking. Here, we combine …

Aberrations in membrane trafficking pathways have profound effects in cellular dynamics of
cellular sorting processes and can drive severe physiological outcomes. Sorting nexin 27 …

Retrograde transport from endosomes to the trans-Golgi network is essential for recycling of
protein and lipid cargoes to counterbalance anterograde membrane traffic. Protein cargo …