Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or
ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists …

Protease-activated receptor 4 (PAR4)(gene F2RL3) harbors a functional dimorphism,
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …

Circulating platelets roll along exposed collagen at vessel injury sites and respond with
filipodia protrusion, shape change, and surface area expansion to facilitate platelet …

Protease activated receptors (PARs) are G-protein coupled receptors (GPCRs) that have a
unique activation mechanism. Unlike other GPCRs that can be activated by free ligands …

Background The effects of docosahexaenoic acid (DHA) on cardiovascular disease are
controversial and a mechanistic understanding of how this omega‐3 polyunsaturated fatty …

Protease-activated receptors (PARs) are a class of integral membrane proteins that are
cleaved by a variety of proteases, most notably thrombin, to reveal a tethered ligand and …

Protease-activated receptors (PARs) are a family of four GPCRs with a variety of cellular
functions, yet the only advanced clinical endeavours to target these receptors for therapeutic …

Background: DNA hypomethylation at the F2RL3 (F2R like thrombin or trypsin receptor 3)
locus has been associated with both smoking and atherosclerotic cardiovascular disease; …

Although procoagulant TF is clearly expressed in the vascular subendothelium, it has also
been proposed that many different cell types express an inactive, encrypted form of TF that …

Platelet activation plays an essential role in clot formation to prevent blood loss following
vascular damage. In pathologic conditions, platelet activation can lead to obstructive clots …