Integrative analysis using omics-based technologies results in the identification of a large
number of putative short open reading frames (sORFs) with protein-coding capacity within …

It is widely suggested that a eukaryotic mRNA typically contains one translation start site and
encodes a single functional protein product. However, according to current points of view on …

The existence of nonannotated protein-coding human short open reading frames (sORFs)
has been revealed through the direct detection of their sORF-encoded polypeptide (SEP) …

Understanding regulatory mechanisms of protein synthesis in eukaryotes is essential for the
accurate annotation of genome sequences. Kozak reported that the nucleotide sequence …

The development of deep sequencing technologies has led to the discovery of novel
transcripts. Many in silico methods have been developed to assess the coding potential of …

Translational control mechanisms are, besides transcriptional control and mRNA stability,
the most determining for final protein levels. A large number of accessory factors that assist …

Background: Patients with Crohn's disease have defects in intestinal epithelial permeability
that are inadequately explained by known inflammatory bowel disease (IBD) susceptibility …

Background Experimental and clinical evidence has pinpointed a critical role for matrix
metalloproteinase-2 (MMP-2) in ischemic ventricular remodeling and systolic heart failure …

Background Eukaryotic ribosomes are widely presumed to scan mRNA for the AUG codon to
initiate translation in a strictly 5′–3′ movement (ie, strictly unidirectional scanning model) …

Alternative start AUG codons within a single transcript can contribute to diversity of the
proteome; however, their functional significance remains controversial. Here, we provide …