Removal of introns from messenger RNA precursors (pre-mRNA splicing) is an essential
step for the expression of most eukaryotic genes. Alternative splicing enables the regulated …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Notable progress has been made in the therapeutic and research applications of cyclic
peptides since our previous review. New drugs based on cyclic peptides are entering the …

The development of potent, specific, and pharmacologically viable chemical probes and
therapeutics is a central focus of chemical biology and therapeutic development. However, a …

Cyclization is an important post-translational modification of peptides and proteins that
confers key advantages such as protection from proteolytic degradation, altered solubility …

Dysregulation of messenger RNA (mRNA) processing—in particular mRNA splicing—is a
hallmark of cancer. Compared to normal cells, cancer cells frequently present aberrant …

Recently splicing has been recognized as a key pathway in cancer. Although aberrant
splicing has been shown to be a consequence of mutations or the abnormal expression of …

Protein secondary and tertiary structure mimics have served as model systems to probe
biophysical parameters that guide protein folding and as attractive reagents to modulate …

The RNA recognition motif (RRM) is the most common RNA binding domain found in the
human proteome. RRM domains provide RNA‐binding proteins with sequence specific RNA …

Interactions between U2AF homology motifs (UHMs) and U2AF ligand motifs (ULMs) play a
crucial role in early spliceosome assembly in eukaryotic gene regulation. UHM-ULM …