DNA mismatch repair in cancer
Microsatellite instability (MSI) refers to the hypermutator phenotype secondary to frequent
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …
polymorphism in short repetitive DNA sequences and single nucleotide substitution, as …
Molecular features and gene expression signature of metastatic colorectal cancer
M Poturnajova, T Furielova, S Balintova… - Oncology …, 2021 - spandidos-publications.com
Uncontrollable metastatic outgrowth process is the leading cause of mortality worldwide,
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …
even in the case of colorectal cancer. Colorectal cancer (CRC) accounts for approximately …
Biomarker concordance between primary colorectal cancer and its metastases
DS Bhullar, J Barriuso, S Mullamitha, MP Saunders… - …, 2019 - thelancet.com
Background The use of biomarkers to target anti-EGFR treatments for metastatic colorectal
cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic …
cancer (CRC) is well-established, requiring molecular analysis of primary or metastatic …
Mesonephric-like adenocarcinoma of the uterine corpus: Genomic and immunohistochemical profiling with comprehensive clinicopathological analysis of 17 …
HH Koh, E Park, HS Kim - Biomedicines, 2023 - mdpi.com
Data on genetic and immunophenotypical characteristics of uterine mesonephric-like
adenocarcinoma (MLA) remain limited. Therefore, we aimed to investigate the …
adenocarcinoma (MLA) remain limited. Therefore, we aimed to investigate the …
Heterogeneity of mismatch repair status and microsatellite instability between primary tumour and metastasis and its implications for immunotherapy in colorectal …
C Evrard, S Messina, D Sefrioui, É Frouin… - International Journal of …, 2022 - mdpi.com
Deficient mismatch repair system (dMMR)/microsatellite instability (MSI) is found in about
5% of metastatic colorectal cancers (mCRCs) with a major therapeutic impact for immune …
5% of metastatic colorectal cancers (mCRCs) with a major therapeutic impact for immune …
Mesonephric-like adenocarcinoma of the uterine corpus: Comparison between mismatch repair protein immunostaining and microsatellite instability testing
Background/Aim: The utility of mismatch repair (MMR) immunohistochemistry (IHC) and
microsatellite instability (MSI) testing in uterine mesonephric-like adenocarcinoma (MLA) …
microsatellite instability (MSI) testing in uterine mesonephric-like adenocarcinoma (MLA) …
Comparison of mismatch repair status between primary and matched metastatic sites in patients with colorectal cancer
WZ He, WM Hu, F Wang, YM Rong, L Yang… - Journal of the National …, 2019 - jnccn.org
Background: Differences between the features of primary cancer and matched metastatic
cancer have recently drawn attention in research. This study investigated the concordance …
cancer have recently drawn attention in research. This study investigated the concordance …
Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors …
S Mishima, H Taniguchi, K Akagi, E Baba… - International Journal of …, 2020 - Springer
Background Novel therapeutic agents have improved survival outcomes in patients with
advanced solid tumors. In parallel, the development of predictive biomarkers to identify …
advanced solid tumors. In parallel, the development of predictive biomarkers to identify …
Discordant loss of mismatch repair proteins in advanced endometrial endometrioid carcinoma compared to paired primary uterine tumors
Objective A subset of endometrial cancer is characterized by deficiencies in the mismatch
repair (MMR) pathway. MMR testing is a well-established tool to screen for Lynch syndrome …
repair (MMR) pathway. MMR testing is a well-established tool to screen for Lynch syndrome …
Heterogeneity of mismatch repair defect in colorectal cancer and its implications in clinical practice
G Tachon, E Frouin, L Karayan-Tapon… - European Journal of …, 2018 - ejcancer.com
Progression of cancer is associated with the accumulation of genetic alterations. These
alterations lead to the emergence of tumoural subclones with different genotypes within the …
alterations lead to the emergence of tumoural subclones with different genotypes within the …