Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity
Mendelian susceptibility to mycobacterial disease (MSMD) is a rare condition characterized
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
by predisposition to clinical disease caused by weakly virulent mycobacteria, such as BCG …
Allogeneic hematopoietic stem cell transplantation for MDS and CMML: recommendations from an international expert panel
T De Witte, D Bowen, M Robin… - Blood, The Journal …, 2017 - ashpublications.org
An international expert panel, active within the European Society for Blood and Marrow
Transplantation, European LeukemiaNet, Blood and Marrow Transplant Clinical Trial Group …
Transplantation, European LeukemiaNet, Blood and Marrow Transplant Clinical Trial Group …
Antigen-presenting cells in the skin
Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes,
and macrophages. They are highly dynamic, with the capacity to enter skin from the …
and macrophages. They are highly dynamic, with the capacity to enter skin from the …
Differential IRF8 transcription factor requirement defines two pathways of dendritic cell development in humans
The formation of mammalian dendritic cells (DCs) is controlled by multiple hematopoietic
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …
transcription factors, including IRF8. Loss of IRF8 exerts a differential effect on DC subsets …
Natural killer cells in myeloid malignancies: immune surveillance, NK cell dysfunction, and pharmacological opportunities to bolster the endogenous NK cells
Natural killer (NK) cells are large granular lymphocytes involved in our defense against
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
certain virus-infected and malignant cells. In contrast to T cells, NK cells elicit rapid anti …
The emerging role of GATA transcription factors in development and disease
MHFM Lentjes, HEC Niessen, Y Akiyama… - Expert reviews in …, 2016 - cambridge.org
The GATA family of transcription factors consists of six proteins (GATA1-6) which are
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
involved in a variety of physiological and pathological processes. GATA1/2/3 are required …
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms
Several monogenic causes of familial myelodysplastic syndrome (MDS) have recently been
identified. We studied 2 families with cytopenia, predisposition to MDS with chromosome 7 …
identified. We studied 2 families with cytopenia, predisposition to MDS with chromosome 7 …
The International Consensus Classification (ICC) of hematologic neoplasms with germline predisposition, pediatric myelodysplastic syndrome, and juvenile …
M Rudelius, OK Weinberg, CM Niemeyer… - Virchows Archiv, 2023 - Springer
Updating the classification of hematologic neoplasia with germline predisposition, pediatric
myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) is critical …
myelodysplastic syndrome (MDS), and juvenile myelomonocytic leukemia (JMML) is critical …
GATA factor mutations in hematologic disease
JD Crispino, MS Horwitz - Blood, The Journal of the American …, 2017 - ashpublications.org
GATA family proteins play essential roles in development of many cell types, including
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …
hematopoietic, cardiac, and endodermal lineages. The first three factors, GATAs 1, 2, and 3 …
Haematopoietic and immune defects associated with GATA2 mutation
Heterozygous familial or sporadic GATA 2 mutations cause a multifaceted disorder,
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …
encompassing susceptibility to infection, pulmonary dysfunction, autoimmunity …