Transmission of arthropod-borne viruses (arboviruses) involves infection and replication in
both arthropod vectors and vertebrate hosts. Nearly all arboviruses are RNA viruses with …

The growing expansion of mosquito vectors has made mosquito-borne arboviral diseases a
global threat to public health, and the lack of licensed vaccines and treatments highlight the …

Variability in how individuals respond to pathogens is a hallmark of infectious disease, yet
the basis for individual variation in host response is often poorly understood. The titer of …

Abstract Historically endemic to Sub-Saharan Africa and South America, yellow fever is
absent from the Asia-Pacific region. Yellow fever virus (YFV) is mainly transmitted by the …

While efforts to control malaria with available tools have stagnated, and arbovirus outbreaks
persist around the globe, the advent of clustered regularly interspaced short palindromic …

Vector competence (VC) refers to the efficiency of pathogen transmission by vectors. Each
step in the infection of a mosquito vector constitutes a barrier to transmission that may …

RNA viruses replicate with low fidelity due to the error-prone nature of the RNA-dependent
RNA polymerase, which generates approximately one mutation per round of genome …

Background To be transmitted to vertebrate hosts via the saliva of their vectors, arthropod-
borne viruses have to cross several barriers in the mosquito body, including the midgut …

The emergence of arthropod-borne viruses (arboviruses) is of global concern as they can
rapidly spread across countries and to new continents as the recent examples of …

The presence of bottlenecks in the transmission cycle of many RNA viruses leads to a
severe reduction of number of virus particles and this occurs multiple times throughout the …