Graph neural networks (GNNs), as a branch of deep learning in non-Euclidean space,
perform particularly well in various tasks that process graph structure data. With the rapid …

Long non-coding RNA (lncRNA) and microRNA (miRNA) are two typical types of non-coding
RNAs (ncRNAs), their interaction plays an important regulatory role in many biological …

Metabolism is the process by which an organism continuously replaces old substances with
new substances. It plays an important role in maintaining human life, body growth and …

Background: Determining drug–disease associations is an integral part in the process of
drug development. However, the identification of drug–disease associations through wet …

Lung cancer is a commonly diagnosed cancer and the leading cause of cancer-related
deaths, posing a serious health risk. Despite new advances in immune checkpoint and …

Identifying new indications for drugs plays an essential role at many phases of drug
research and development. Computational methods are regarded as an effective way to …

In silico reuse of old drugs (also known as drug repositioning) to treat common and rare
diseases is increasingly becoming an attractive proposition because it involves the use of de …

Everything is connected and thus networks are instrumental in not only modeling complex
systems with many components, but also accommodating knowledge about their …

Motivation Human microbes play critical roles in drug development and precision medicine.
How to systematically understand the complex interaction mechanism between human …

Studies have shown that the mechanism of action of many drugs is related to miRNA. In-
depth research on the relationship between miRNA and drugs can provide theoretical …