Metabolic reprogramming in renal cancer: events of a metabolic disease
Recent studies have established that tumors can reprogram the pathways involved in
nutrient uptake and metabolism to withstand the altered biosynthetic, bioenergetics and …
nutrient uptake and metabolism to withstand the altered biosynthetic, bioenergetics and …
Choosing the right cell line for renal cell cancer research
Cell lines are still a tool of choice for many fields of biomedical research, including oncology.
Although cancer is a very complex disease, many discoveries have been made using …
Although cancer is a very complex disease, many discoveries have been made using …
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
R Hoefflin, S Harlander, S Schäfer, P Metzger… - Nature …, 2020 - nature.com
Mutational inactivation of VHL is the earliest genetic event in the majority of clear cell renal
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …
cell carcinomas (ccRCC), leading to accumulation of the HIF-1α and HIF-2α transcription …
PBRM1 deficiency confers synthetic lethality to DNA repair inhibitors in cancer
RM Chabanon, D Morel, T Eychenne, L Colmet-Daage… - Cancer research, 2021 - AACR
Abstract Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin
remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …
remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …
Epigenetics in renal cell cancer: mechanisms and clinical applications
SC Joosten, KM Smits, MJ Aarts, V Melotte… - Nature Reviews …, 2018 - nature.com
Renal cell carcinoma (RCC) is characterized by an infrequent number of somatic mutations.
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …
By contrast, epigenetic aberrations are commonly found in RCC, indicating that epigenetic …
Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/− clear cell renal carcinoma
Most clear cell renal carcinomas (ccRCCs) are initiated by somatic inactivation of the VHL
tumor suppressor gene. The VHL gene product, pVHL, is the substrate recognition unit of an …
tumor suppressor gene. The VHL gene product, pVHL, is the substrate recognition unit of an …
Prognostic and Predictive Value of PBRM1 in Clear Cell Renal Cell Carcinoma
L Carril-Ajuria, M Santos, JM Roldán-Romero… - Cancers, 2019 - mdpi.com
Renal cell carcinoma (RCC) is the most frequent kidney solid tumor, the clear cell RCC
(ccRCC) being the major histological subtype. The probability of recurrence and the clinical …
(ccRCC) being the major histological subtype. The probability of recurrence and the clinical …
The epigenetic landscape of renal cancer
MR Morris, F Latif - Nature Reviews Nephrology, 2017 - nature.com
The majority of kidney cancers are associated with mutations in the von Hippel-Lindau gene
and a small proportion are associated with infrequent mutations in other well characterized …
and a small proportion are associated with infrequent mutations in other well characterized …
PI3K/AKT/mTOR dysregulation and reprogramming metabolic pathways in renal cancer: Crosstalk with the VHL/HIF axis
Renal cell carcinoma (RCC) represents 85–95% of kidney cancers and is the most frequent
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …
type of renal cancer in adult patients. It accounts for 3% of all cancer cases and is in 7th …
Epigenetic modifiers: activities in renal cell carcinoma
Renal cell carcinomas (RCCs) are a diverse set of malignancies that have recently been
shown to harbour mutations in a number of chromatin modifier genes—including PBRM1 …
shown to harbour mutations in a number of chromatin modifier genes—including PBRM1 …