Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and
bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form …

The desired mechanical and biological performances of collagen that have led to its broad
application as a building block in the biomedical field attributed to its intrinsic hierarchical …

This chapter looks at variables such as fibril diameter, orientation, tissue distribution, relative
concentrations and packing of fibrils into larger volumes, and search for patterns which …

The formation of collagen fibrils, fibril bundies, and tissue-specific collagen
macroaggregates by chick embryo tendon fibroblasts was studied using conventional and …

Type I procollagen was purified from the medium of cultured human fibroblasts incubated
with 14C-labeled amino acids, the NH2-terminal propeptides were cleaved with procollagen …

Intensive research in the last decade has revealed a wealth of detail on the mechanism of
biosynthesis, molecular structure, and covalent cross-linking of collagen. Tissues of higher …

The regulation of collagen fibril, bundle, and lamella formation by the corneal fibroblasts, as
well as the organization of these elements into an orthogonal stroma, was studied by …

The longitudinal growth of bone depends on the activities of individual chondrocytes of the
growth plate. Each chondrocyte remains in a fixed location throughout its life, and there …

Collagen is the single most abundant animal protein in mammals accounting for about 30%
of all proteins. The collagen molecules, after being secreted by the cells, assemble into …

Publisher Summary This chapter discusses the differentiated state of normal and malignant
cells. The first step of cell separation (trypsinization and collagenase treatment), by removing …