BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Skeletal muscle regeneration is a complex process, which is not yet completely understood.
Satellite cells, the skeletal muscle stem cells, become activated after trauma, proliferate, and …

Muscular dystrophies are a heterogeneous group of genetic diseases, characterized by
progressive degeneration of skeletal and cardiac muscle. Despite the intense investigation …

In skeletal muscles, levels and activity of Matrix MetalloProteinases (MMPs) and Tissue
Inhibitors of MetalloProteinases (TIMPs) have been involved in myoblast migration, fusion …

Muscle recently has been identified as a good source of adult stem cells that can
differentiate into cells of different lineages. The most well-known muscle progenitor cells are …

Satellite cells are considered to be adult skeletal muscle stem cells. Their ability to
regenerate large muscle defects is highly dependent on their specific niche. When these …

Directional cell migration is a critical process underlying morphogenesis and post‐natal
tissue regeneration. During embryonic myogenesis, migration of skeletal myogenic …

Migration of transplanted myogenic cells occurs during both embryogenesis and
regeneration of skeletal muscles and is important for successful myoblast transplantation …

Nonhuman primates were used to define myoblast transplantation strategies applicable to
humans. Nevertheless, previous experiments were based on the use of myotoxins …

The implantation of cultured myogenic cells into the body (myoblast transplantation) is an
experimental strategy that is being explored for the potential treatment of myopathies. Its …