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Treatment landscape of triple-negative breast cancer—expanded options, evolving needs
Tumour heterogeneity and a long-standing paucity of effective therapies other than
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …
chemotherapy have contributed to triple-negative breast cancer (TNBC) being the subtype …
Biomarkers for breast cancer immunotherapy: PD-L1, TILs, and beyond
A Rizzo, AD Ricci - Expert opinion on investigational drugs, 2022 - Taylor & Francis
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) have recently entered into the
therapeutic scenario of metastatic breast cancer. However, only a proportion of patients …
therapeutic scenario of metastatic breast cancer. However, only a proportion of patients …
The single‐cell landscape of intratumoral heterogeneity and the immunosuppressive microenvironment in liver and brain metastases of breast cancer
Distant metastasis remains the major cause of morbidity for breast cancer. Individuals with
liver or brain metastasis have an extremely poor prognosis and low response rates to anti …
liver or brain metastasis have an extremely poor prognosis and low response rates to anti …
[HTML][HTML] Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery
Background Postoperative progression and chemotherapy resistance is the major cause of
treatment failure in patients with triple-negative breast cancer (TNBC). Currently, there is a …
treatment failure in patients with triple-negative breast cancer (TNBC). Currently, there is a …
Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
The cellular and molecular mechanisms underlying tumor cell PD-L1 (tPD-L1) function in
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …
tumor immune evasion are incompletely understood. We report here that tPD-L1 does not …
Tumor-infiltrating lymphocytes for treatment of solid tumors: It takes two to tango?
Tumor-infiltrating lymphocytes (TILs), frontline soldiers of the adaptive immune system, are
recruited into the tumor site to fight against tumors. However, their small number and …
recruited into the tumor site to fight against tumors. However, their small number and …
[HTML][HTML] The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment
The tumour microenvironment is of critical importance in cancer development and
progression and includes the surrounding stromal and immune cells, extracellular matrix …
progression and includes the surrounding stromal and immune cells, extracellular matrix …
Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer
Cancer-associated fibroblasts (CAFs) are essential for tumor microenvironment remodeling
and correlate with tumor progression. However, interactions between CAFs and tumor cells …
and correlate with tumor progression. However, interactions between CAFs and tumor cells …
Prognostic and therapeutic role of tumor-infiltrating lymphocyte subtypes in breast cancer
Increased levels of total tumor-infiltrating lymphocytes (TILs) are generally associated with
good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells …
good prognosis in several breast cancer subtypes. Subtypes of TILs impact both tumor cells …
Dissecting the role of cancer‐associated fibroblast‐derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single‐cell …
Abstract Introduction Cancer‐associated fibroblasts (CAFs) are correlated with the
immunotherapy response. However, the culprits that link CAFs to immunotherapy resistance …
immunotherapy response. However, the culprits that link CAFs to immunotherapy resistance …