Plasmodium—a brief introduction to the parasites causing human malaria and their basic biology

S Sato - Journal of physiological anthropology, 2021 - Springer
Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

Malaria: biology and disease

AF Cowman, J Healer, D Marapana, K Marsh - Cell, 2016 - cell.com
Malaria has been a major global health problem of humans through history and is a leading
cause of death and disease across many tropical and subtropical countries. Over the last …

Uncovering the essential genes of the human malaria parasite Plasmodium falciparum by saturation mutagenesis

M Zhang, C Wang, TD Otto, J Oberstaller, X Liao… - Science, 2018 - science.org
INTRODUCTION Malaria remains a devastating global parasitic disease, with the majority of
malaria deaths caused by the highly virulent Plasmodium falciparum. The extreme AT-bias …

Ultrasensitive CRISPR-based diagnostic for field-applicable detection of Plasmodium species in symptomatic and asymptomatic malaria

RA Lee, HD Puig, PQ Nguyen… - Proceedings of the …, 2020 - pnas.org
Asymptomatic carriers of Plasmodium parasites hamper malaria control and eradication.
Achieving malaria eradication requires ultrasensitive diagnostics for low parasite density …

Circlator: automated circularization of genome assemblies using long sequencing reads

M Hunt, ND Silva, TD Otto, J Parkhill, JA Keane… - Genome biology, 2015 - Springer
The assembly of DNA sequence data is undergoing a renaissance thanks to emerging
technologies capable of producing reads tens of kilobases long. Assembling complete …

Generating high quality libraries for DIA MS with empirically corrected peptide predictions

BC Searle, KE Swearingen, CA Barnes… - Nature …, 2020 - nature.com
Data-independent acquisition approaches typically rely on experiment-specific spectrum
libraries, requiring offline fractionation and tens to hundreds of injections. We demonstrate a …

Advances and opportunities in malaria population genomics

DE Neafsey, AR Taylor, BL MacInnis - Nature Reviews Genetics, 2021 - nature.com
Almost 20 years have passed since the first reference genome assemblies were published
for Plasmodium falciparum, the deadliest malaria parasite, and Anopheles gambiae, the …

The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA …

JF Armstrong, E Faccenda, SD Harding… - Nucleic acids …, 2020 - academic.oup.com
Abstract The IUPHAR/BPS Guide to PHARMACOLOGY (www. guidetopharmacology. org) is
an open-access, expert-curated database of molecular interactions between ligands and …

DNA topoisomerases: Advances in understanding of cellular roles and multi‐protein complexes via structure‐function analysis

SJ McKie, KC Neuman, A Maxwell - Bioessays, 2021 - Wiley Online Library
DNA topoisomerases, capable of manipulating DNA topology, are ubiquitous and
indispensable for cellular survival due to the numerous roles they play during DNA …

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

MA Quail, M Smith, P Coupland, TD Otto, SR Harris… - BMC genomics, 2012 - Springer
Background Next generation sequencing (NGS) technology has revolutionized genomic and
genetic research. The pace of change in this area is rapid with three major new sequencing …