Defining NAD (P)(H) Catabolism

J Dhuguru, RW Dellinger, ME Migaud - Nutrients, 2023 - mdpi.com
Dietary vitamin B3 components, such as nicotinamide and nicotinic acid, are precursors to
the ubiquitous redox cofactor nicotinamide adenine dinucleotide (NAD+). NAD+ levels are …

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

X Pan, ML Heacock, EN Abdulaziz, S Violante… - Nature chemical …, 2024 - nature.com
Impaired redox metabolism is a key contributor to the etiology of many diseases, including
primary mitochondrial disorders, cancer, neurodegeneration and aging. However …

Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target

B Petriti, PA Williams, G Lascaratos, KY Chau… - Cells, 2021 - mdpi.com
Glaucoma is the leading cause of irreversible blindness worldwide. Its prevalence and
incidence increase exponentially with age and the level of intraocular pressure (IOP). IOP …

Lutein shows a protective effect against the aging of mesenchymal stem cells by downregulating inflammation

K Zhao, T Zhou, J Yang, Y Li, J Qin, S Wang… - International …, 2023 - Elsevier
Currently, many countries in the world are entering an aging society. The health of the
elderly is the most prominent problem in an aging society. Stem cell exhaustion and aging …

Toying with reductive stress

AC Murphy, MR McReynolds - Nature Chemical Biology, 2024 - nature.com
Toying with reductive stress | Nature Chemical Biology Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

Preservation of an Aging-Associated Mitochondrial Signature in Advanced Human Neuronal Models

N Varghese, L Szabo, Z Cader, I Lejri, A Grimm… - bioRxiv, 2024 - biorxiv.org
This study investigated whether induced pluripotent stem cell-derived neurons (iPSCsNs)
and directly converted neurons (iNs) generated from the same cells of origin (human …

A genetically encoded tool to increase cellular NADH/NAD+ ratio in living cells

ML Heacock, EN Abdulaziz, X Pan, AL Zuckerman… - bioRxiv, 2022 - biorxiv.org
Impaired reduction/oxidation (redox) metabolism is a key contributor to the etiology of many
diseases, including primary mitochondrial disorders, cancer, neurodegeneration, and aging …

[PDF][PDF] Progress in research on mechanism of nicotinamide adenine dinucleotide and its precursors against aging-related diseases

S ZHENG, J LÜ, S GUO, X YANG, Z HE - Chinese Journal of Public …, 2023 - zgggws.com
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme of various dehydrogenases,
which plays an important role in physiological processes such as glycolysis and tricarboxylic …

[PDF][PDF] 烟酰胺腺嘌呤二核苷酸及其前体防治衰老相关疾病作用机制研究进展

郑世雄, 吕婧, 郭沈涛, 杨杏芬, 何志妮 - **公共卫生, 2023 - zgggws.com
烟酰胺腺嘌呤二核苷酸(nicotinamide adenine dinucleotide, NAD+) 是多种脱氢酶的辅酶,
在糖酵解, 三羧酸循环等生理过程中发挥着重要作用, 并参与能量代谢, 蛋白质翻译和修饰, DNA …

[PDF][PDF] Aging is selected for, adaptive and programmed. 26. Aging is a somatic survival program, resisting germline-imposed death

K Heininger - researchgate.net
Scientists have been vexed by findings that the soma presents both pro-aging and anti-
aging features and mechanisms. The biological processes that accompany aging are …