Cardiometabolic health, diet and the gut microbiome: a meta-omics perspective
Cardiometabolic diseases have become a leading cause of morbidity and mortality globally.
They have been tightly linked to microbiome taxonomic and functional composition, with diet …
They have been tightly linked to microbiome taxonomic and functional composition, with diet …
The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease
RM Chakaroun, LM Olsson, F Bäckhed - Nature Reviews Cardiology, 2023 - nature.com
Despite milestones in preventive measures and treatment, cardiovascular disease (CVD)
remains associated with a high burden of morbidity and mortality. The protracted nature of …
remains associated with a high burden of morbidity and mortality. The protracted nature of …
Roles of the gut microbiome in weight management
Overweight, obesity, undernutrition and their respective sequelae have devastating tolls on
personal and public health worldwide. Traditional approaches for treating these conditions …
personal and public health worldwide. Traditional approaches for treating these conditions …
Understanding the molecular mechanisms of statin pleiotropic effects
CA German, JK Liao - Archives of Toxicology, 2023 - Springer
Statins represent the cornerstone of pharmacotherapy for the prevention of atherosclerotic
cardiovascular disease. These medications not only reduce low-density lipoprotein …
cardiovascular disease. These medications not only reduce low-density lipoprotein …
The transition from genomics to phenomics in personalized population health
Modern health care faces several serious challenges, including an ageing population and
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
its inherent burden of chronic diseases, rising costs and marginal quality metrics. By …
Pharma [e] cology: how the gut microbiome contributes to variations in drug response
KR Trepka, CA Olson, V Upadhyay… - Annual Review of …, 2024 - annualreviews.org
Drugs represent our first, and sometimes last, line of defense for many diseases, yet despite
decades of research we still do not fully understand why a given drug works in one patient …
decades of research we still do not fully understand why a given drug works in one patient …
[HTML][HTML] Exploring the potential impact of probiotic use on drug metabolism and efficacy
Probiotics are frequently consumed as functional food and widely used as dietary
supplements, but are also recommended in treating or preventing various gastrointestinal …
supplements, but are also recommended in treating or preventing various gastrointestinal …
[HTML][HTML] Perspective: leveraging the gut microbiota to predict personalized responses to dietary, prebiotic, and probiotic interventions
Humans often show variable responses to dietary, prebiotic, and probiotic interventions.
Emerging evidence indicates that the gut microbiota is a key determinant for this population …
Emerging evidence indicates that the gut microbiota is a key determinant for this population …
Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
To understand the dynamic interplay between the human microbiome and host during
health and disease, we analyzed the microbial composition, temporal dynamics, and …
health and disease, we analyzed the microbial composition, temporal dynamics, and …
Digesting the complex metabolic effects of diet on the host and microbiome
The past 50 years of interdisciplinary research in humans and model organisms has
delivered unprecedented insights into the mechanisms through which diet affects energy …
delivered unprecedented insights into the mechanisms through which diet affects energy …