Mito‐bomb: targeting mitochondria for cancer therapy

X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …

Chemically modified and conjugated antimicrobial peptides against superbugs

W Li, F Separovic, NM O'Brien-Simpson… - Chemical Society …, 2021 - pubs.rsc.org
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …

Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes

I Nakase, NB Kobayashi, T Takatani-Nakase… - Scientific reports, 2015 - nature.com
Exosomes are approximately 100-nm vesicles that consist of a lipid bilayer of cellular
membranes secreted in large quantities from various types of normal and disease-related …

Tumor acidity activating multifunctional nanoplatform for NIR-mediated multiple enhanced photodynamic and photothermal tumor therapy

J Liu, H Liang, M Li, Z Luo, J Zhang, X Guo, K Cai - Biomaterials, 2018 - Elsevier
The study reports a multifunctional nanoplatform based on mesoporous silica coated gold
nanorod (AuNR@ MSN) to overcome biological barriers associating with nanocarrier for …

Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

I Nakase, S Futaki - Scientific reports, 2015 - nature.com
Exosomes, which are approximately 100 nm vesicles secreted by cells, have been studied
with respect to cell-to-cell communication, disease diagnosis and intracellular delivery. The …

Peptides and peptidomimetics for antimicrobial drug design

B Mojsoska, H Jenssen - Pharmaceuticals, 2015 - mdpi.com
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …

Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

I Nakase, K Noguchi, A Aoki, T Takatani-Nakase… - Scientific reports, 2017 - nature.com
Extracellular vesicles (EVs) including exosomes have been shown to play crucial roles in
cell-to-cell communication because of their ability to carry biofunctional molecules (eg …

[HTML][HTML] Role of arginine and lysine in the antimicrobial mechanism of histone-derived antimicrobial peptides

KJ Cutrona, BA Kaufman, DM Figueroa, DE Elmore - FEBS letters, 2015 - Elsevier
Translocation of cell-penetrating peptides is often promoted by increased content of arginine
or other guanidinium groups. However, relatively little research has considered the role of …

[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment

AG Mukherjee, UR Wanjari, AV Gopalakrishnan… - Biomedicine & …, 2023 - Elsevier
Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …

Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

I Nakase, M Katayama, Y Hattori, M Ishimura… - Chemical …, 2019 - pubs.rsc.org
In this study, we designed and synthesized organelle-targeted cell-penetrating peptide
(CPP)-conjugated boron compounds to increase their cellular uptake and to control the …