Mito‐bomb: targeting mitochondria for cancer therapy
X Guo, N Yang, W Ji, H Zhang, X Dong… - Advanced …, 2021 - Wiley Online Library
Cancer has been one of the most common life‐threatening diseases for a long time.
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …
Traditional cancer therapies such as surgery, chemotherapy (CT), and radiotherapy (RT) …
Chemically modified and conjugated antimicrobial peptides against superbugs
Antimicrobial resistance (AMR) is one of the greatest threats to human health that, by 2050,
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
will lead to more deaths from bacterial infections than cancer. New antimicrobial agents …
Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes
I Nakase, NB Kobayashi, T Takatani-Nakase… - Scientific reports, 2015 - nature.com
Exosomes are approximately 100-nm vesicles that consist of a lipid bilayer of cellular
membranes secreted in large quantities from various types of normal and disease-related …
membranes secreted in large quantities from various types of normal and disease-related …
Tumor acidity activating multifunctional nanoplatform for NIR-mediated multiple enhanced photodynamic and photothermal tumor therapy
J Liu, H Liang, M Li, Z Luo, J Zhang, X Guo, K Cai - Biomaterials, 2018 - Elsevier
The study reports a multifunctional nanoplatform based on mesoporous silica coated gold
nanorod (AuNR@ MSN) to overcome biological barriers associating with nanocarrier for …
nanorod (AuNR@ MSN) to overcome biological barriers associating with nanocarrier for …
Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes
I Nakase, S Futaki - Scientific reports, 2015 - nature.com
Exosomes, which are approximately 100 nm vesicles secreted by cells, have been studied
with respect to cell-to-cell communication, disease diagnosis and intracellular delivery. The …
with respect to cell-to-cell communication, disease diagnosis and intracellular delivery. The …
Peptides and peptidomimetics for antimicrobial drug design
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …
antimicrobial peptides with a focus on structure-activity relationship studies. After first …
Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery
I Nakase, K Noguchi, A Aoki, T Takatani-Nakase… - Scientific reports, 2017 - nature.com
Extracellular vesicles (EVs) including exosomes have been shown to play crucial roles in
cell-to-cell communication because of their ability to carry biofunctional molecules (eg …
cell-to-cell communication because of their ability to carry biofunctional molecules (eg …
[HTML][HTML] Role of arginine and lysine in the antimicrobial mechanism of histone-derived antimicrobial peptides
KJ Cutrona, BA Kaufman, DM Figueroa, DE Elmore - FEBS letters, 2015 - Elsevier
Translocation of cell-penetrating peptides is often promoted by increased content of arginine
or other guanidinium groups. However, relatively little research has considered the role of …
or other guanidinium groups. However, relatively little research has considered the role of …
[HTML][HTML] Evolving strategies and application of proteins and peptide therapeutics in cancer treatment
Several proteins and peptides have therapeutic potential and can be used for cancer
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …
therapy. By binding to cell surface receptors and other indicators uniquely linked with or …
Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)
I Nakase, M Katayama, Y Hattori, M Ishimura… - Chemical …, 2019 - pubs.rsc.org
In this study, we designed and synthesized organelle-targeted cell-penetrating peptide
(CPP)-conjugated boron compounds to increase their cellular uptake and to control the …
(CPP)-conjugated boron compounds to increase their cellular uptake and to control the …