Polycyclic aromatic hydrocarbons (PAHs) are a class of chemicals of considerable
environmental significance. PAHs are chemical contaminants of fused carbon and hydrogen …

Endothelium plays a fundamental role in the cardiovascular system, forming an interface
between blood and adjacent tissues by regulating the vascular tone through the synthesis of …

Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and
its antiatherogenic properties support cardiovascular homeostasis. Diminished NO …

Recent clinical trials have shown that sodium glucose co-transport 2 (SGLT2) inhibitors have
dramatic beneficial cardiovascular outcomes. These include a reduced incidence of …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused
by SARS-CoV-2 virus, has posed a serious threat to global public health and caused …

Hypertension is a major risk factor for many common chronic diseases, such as heart failure,
myocardial infarction, stroke, vascular dementia, and chronic kidney disease …

In the past, endothelium was thought to be only a mechanical barrier. Today, endothelium is
known to be a tissue regulating vascular tone, cell growth and the interaction between the …

Endothelial dysfunction is a major contributing factor to diseases such as atherosclerosis,
diabetes mellitus, obesity, hypertension, acute lung injury, preeclampsia, among others …

Redox homeostasis is a delicate balancing act of maintaining appropriate levels of
antioxidant defense mechanisms and reactive oxidizing oxygen and nitrogen species. Any …