In The Lancet, we have published the findings of the Global Burden of Diseases, Injuries,
and Risk Factors Study (GBD) 2021 in a series of six Articles. 1–6 GBD began in 1991 and …

Aim To (i) assess the prevalence, incidence, and burden of severe periodontitis and
edentulism in 2021, and (ii) forecast their rates in 2050. Methods Prevalence, incidence, and …

Background Antimicrobial resistance (AMR) poses an important global health challenge in
the 21st century. A previous study has quantified the global and regional burden of AMR for …

Background Over the past several decades, the overweight and obesity epidemic in the USA
has resulted in a significant health and economic burden. Understanding current trends and …

Background The six global nutrition targets (GNTs) related to low birthweight, exclusive
breastfeeding, child growth (ie, wasting, stunting, and overweight), and anaemia among …

The long delay before genomic technologies become available in low-and middle-income
countries is a concern from both scientific and ethical standpoints. Polygenic risk scores …

Summary Background The Global Burden of Diseases, Injuries, and Risk Factors Study
(GBD) 2021 provides a comprehensive assessment of health and risk factor trends at global …

Importance Health-adjusted life expectancy, a measure of healthy longevity, lags longevity
gains, resulting in a healthspan-lifespan gap. Objective To quantify the healthspan-lifespan …

Background GLP-1 receptor agonists reduce the risk of major adverse cardiovascular events
(MACE) and can also have kidney benefits. However, whether GLP-1 receptor agonists …

Background The capacity to anticipate future health issues is important for both policy
makers and practitioners in the USA, as such insights can facilitate effective planning …