Recent progress of microfluidic reactors for biomedical applications

H Shi, K Nie, B Dong, M Long, H Xu, Z Liu - Chemical Engineering Journal, 2019 - Elsevier
Lab-on-a-chip has evolved into a powerful analytical tool that combines multiple disciplines
for biomedical research. The microfluidic reactor in lab-on-a-chip is regarded as a critical …

Digital detection of proteins

DC Duffy - Lab on a Chip, 2023 - pubs.rsc.org
This paper reviews methods for detecting proteins based on molecular digitization, ie, the
isolation and detection of single protein molecules or singulated ensembles of protein …

Integrated immunoisolation and protein analysis of circulating exosomes using microfluidic technology

M He, J Crow, M Roth, Y Zeng, AK Godwin - Lab on a Chip, 2014 - pubs.rsc.org
Develo** blood-based tests is appealing for non-invasive disease diagnosis, especially
when biopsy is difficult, costly, and sometimes not even an option. Tumor-derived exosomes …

Cellphone-based hand-held microplate reader for point-of-care testing of enzyme-linked immunosorbent assays

B Berg, B Cortazar, D Tseng, H Ozkan, S Feng, Q Wei… - ACS …, 2015 - ACS Publications
Standard microplate based enzyme-linked immunosorbent assays (ELISA) are widely
utilized for various nanomedicine, molecular sensing, and disease screening applications …

Multiplexed immunophenoty** of circulating exosomes on nano-engineered ExoProfile chip towards early diagnosis of cancer

P Zhang, X Zhou, Y Zeng - Chemical science, 2019 - pubs.rsc.org
Circulating exosomes have been studied as a promising biomarker for non-invasive cancer
diagnosis, as they are implicated in tumor initiation, progression, and metastasis. However …

Integrated biosensor for rapid and point-of-care sepsis diagnosis

J Min, M Nothing, B Coble, H Zheng, J Park, H Im… - Acs Nano, 2018 - ACS Publications
Sepsis is an often fatal condition that arises when the immune response to an infection
causes widespread systemic organ injury. A critical unmet need in combating sepsis is the …

Molecular and functional extracellular vesicle analysis using nanopatterned microchips monitors tumor progression and metastasis

P Zhang, X Wu, G Gardashova, Y Yang… - Science translational …, 2020 - science.org
Longitudinal cancer monitoring is crucial to clinical implementation of precision medicine.
There is growing evidence indicating important functions of extracellular vesicles (EVs) in …

[HTML][HTML] A paper-based device for performing loop-mediated isothermal amplification with real-time simultaneous detection of multiple DNA targets

Y Seok, HA Joung, JY Byun, HS Jeon, SJ Shin… - Theranostics, 2017 - ncbi.nlm.nih.gov
Paper-based diagnostic devices have many advantages as a one of the multiple diagnostic
test platforms for point-of-care (POC) testing because they have simplicity, portability, and …

Biochemical analysis on microfluidic chips

J Wu, Z He, Q Chen, JM Lin - TrAC Trends in Analytical Chemistry, 2016 - Elsevier
Biochemical analysis is crucial in understanding mechanism of life activities and giving
biological insights into life process. With inherent merits in flexible design, microscale of …

Development of a high-throughput centrifugal microsystem for enzyme-linked immunosorbent assay to detect SARS-CoV-2

H Van Nguyen, J Yang, H Van Nguyen, H Poo… - Chemical Engineering …, 2023 - Elsevier
Enzyme-linked immunosorbent assay (ELISA) is a commonly used diagnostic and
quantification tool for protein biomarkers in biomedical research and industrial quality …