Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials

B Gencer, NA Marston, KA Im, CP Cannon, P Sever… - The Lancet, 2020 - thelancet.com
Background The clinical benefit of LDL cholesterol lowering treatment in older patients
remains debated. We aimed to summarise the evidence of LDL cholesterol lowering …

Nutraceuticals: A paradigm of proactive medicine

A Santini, GC Tenore, E Novellino - European Journal of Pharmaceutical …, 2017 - Elsevier
Nutraceuticals define a new category which shades the frontier between drugs and food. As
per its definition, a nutraceutical is “a food or part of a food that provides benefits health in …

[HTML][HTML] Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials

J Armitage, C Baigent, E Barnes, DJ Betteridge… - The Lancet, 2019 - thelancet.com
Background Statin therapy has been shown to reduce major vascular events and vascular
mortality in a wide range of individuals, but there is uncertainty about its efficacy and safety …

Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017

M Kinoshita, K Yokote, H Arai, M Iida… - … of atherosclerosis and …, 2018 - jstage.jst.go.jp
Every 5 years, the JAS publishes guidelines for the treatment of dyslipidemia and
atherosclerosis. To date, this society has released four such guidelines. Since 2007, the JAS …

[HTML][HTML] National Lipid Association recommendations for patient-centered management of dyslipidemia: part 2

TA Jacobson, KC Maki, CE Orringer, PH Jones… - Journal of clinical …, 2015 - Elsevier
Abstract An Expert Panel convened by the National Lipid Association previously developed
a consensus set of recommendations for the patient-centered management of dyslipidemia …

Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study

R Ramos, M Comas-Cufí, R Martí-Lluch, E Balló… - bmj, 2018 - bmj.com
Objective To assess whether statin treatment is associated with a reduction in
atherosclerotic cardiovascular disease (CVD) and mortality in old and very old adults with …

Diagnosis, prevention, and management of statin adverse effects and intolerance: Canadian Consensus Working Group Update (2016)

GBJ Mancini, S Baker, J Bergeron, D Fitchett… - Canadian Journal of …, 2016 - Elsevier
Abstract The Canadian Consensus Working Group has updated its evaluation of the
literature pertaining to statin intolerance and adverse effects. This overview introduces a …

Immune reconstitution inflammatory syndrome in patients starting antiretroviral therapy for HIV infection: a systematic review and meta-analysis

M Müller, S Wandel, R Colebunders, S Attia… - The Lancet infectious …, 2010 - thelancet.com
In patients with HIV-1 infection who are starting combination antiretroviral therapy (ART), the
incidence of immune reconstitution inflammatory syndrome (IRIS) is not well defined. We did …

Comparative tolerability and harms of individual statins: a study-level network meta-analysis of 246 955 participants from 135 randomized, controlled trials

H Naci, J Brugts, T Ades - Circulation: Cardiovascular Quality and …, 2013 - Am Heart Assoc
Background—Our objective was to estimate the comparative harms of individual statins
using both placebo-controlled and active-comparator trials. Methods and Results—We …

Influenza vaccine as a coronary intervention for prevention of myocardial infarction

CR MacIntyre, A Mahimbo, AM Moa, M Barnes - Heart, 2016 - heart.bmj.com
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally.
Influenza is one of the leading infectious causes of morbidity and mortality globally, and …