In 2014, FIGO's Committee for Gynecologic Oncology revised the staging of ovarian cancer,
incorporating ovarian, fallopian tube, and peritoneal cancer into the same system. Most of …

Scientists in this field often joke," If you don't have a mechanism, say it's ROS." Seemingly
connected to every biological process ever described, reactive oxygen species (ROS) have …

PURPOSE To provide precise age-specific risk estimates of cancers other than female
breast and ovarian cancers associated with pathogenic variants (PVs) in BRCA1 and …

Germ line DDX41 variants have been implicated in late-onset myeloid neoplasms (MNs).
Despite an increasing number of publications, many important features of DDX41-mutated …

The NCCN Guidelines for Prostate Cancer include recommendations regarding diagnosis,
risk stratification and workup, treatment options for localized disease, and management of …

Genome editing has potential for the targeted correction of germline mutations. Here we
describe the correction of the heterozygous MYBPC3 mutation in human preimplantation …

The envelope spike (S) proteins of MERS-CoV and SARS-CoV determine the virus host
tropism and entry into host cells, and constitute a promising target for the development of …

Between the years 2010 and 2012, the lifetime probability of develo** female breast
cancer was 12.3%, or approximately 1 in 8. Worldwide, breast cancer is the most common …

Background For more than a decade, risk stratification for hypertrophic cardiomyopathy has
been enhanced by targeted genetic testing. Using sequencing results, clinicians routinely …

The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been
reported in single populations, with the majority of reports focused on White in Europe and …