IgG antibodies mediate a diversity of immune functions by coupling of antigen specificity
through the Fab domain to signal transduction via Fc-Fc receptor interactions. Indeed …

A key determinant for the survival of an organism is the ability to recognize and respond to
invading pathogens without damaging host tissues. This is accomplished largely by the …

There is a growing appreciation for the contribution of platelets to immunity; however, our
knowledge mostly relies on platelet functions associated with vascular injury and the …

Fc-gamma receptors (FcγR) are the cellular receptors for Immunoglobulin G (IgG). Upon
binding of complexed IgG, FcγRs can trigger various cellular immune effector functions …

The immune system is comprised of two principal interconnected components called innate
and adaptive immunity. While the innate immune system mounts a nonspecific response that …

Sepsis and autoimmune diseases remain major causes of morbidity and mortality. The last
decade has seen a new appreciation of platelets in host defense, in both immunity and …

Fcγ receptors have critical roles in the pathophysiology of heparin-induced
thrombocytopenia (HIT), a severe immune-mediated complication of heparin treatment …

Fc gamma receptors (FcγRs) are a family of receptors that bind IgG antibodies and interface
at the junction of humoral and innate immunity. Precise regulation of receptor expression …

In this study, we aimed to identify an essential blood molecular signature for chacterizing the
progression of sepsis-induced acute lung injury using integrated bioinformatic and machine …

Intravenous Ig is used to treat autoimmune or autoinflammatory disorders, but the
mechanism by which it exerts its immunosuppressive activity is not understood completely …