Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
[HTML][HTML] Neurodevelopmental disorders: Metallomics studies for the identification of potential biomarkers associated to diagnosis and treatment
C Scassellati, C Bonvicini, L Benussi, R Ghidoni… - Journal of Trace …, 2020 - Elsevier
Background Diagnosis and treatment of complex diseases such as Neurodevelopmental
Disorders (NDDs) can be resolved through the identification of biomarkers. Metallomics …
Disorders (NDDs) can be resolved through the identification of biomarkers. Metallomics …
Zika virus impairs growth in human neurospheres and brain organoids
Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased
considerably in Brazil; however, causality between the viral epidemic and malformations in …
considerably in Brazil; however, causality between the viral epidemic and malformations in …
Modeling psychiatric disorders: from genomic findings to cellular phenotypes
Major programs in psychiatric genetics have identified> 150 risk loci for psychiatric
disorders. These loci converge on a small number of functional pathways, which span …
disorders. These loci converge on a small number of functional pathways, which span …
hiPSC-derived neural stem cells from patients with schizophrenia induce an impaired angiogenesis
BS Casas, G Vitória, MN do Costa… - Translational …, 2018 - nature.com
Schizophrenia is a neurodevelopmental disease characterized by cerebral connectivity
impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) …
impairment and loss of gray matter. It was described in adult schizophrenia patients (SZP) …
Tracing early neurodevelopment in schizophrenia with induced pluripotent stem cells
Schizophrenia (SCZ) is a devastating mental disorder that is characterized by distortions in
thinking, perception, emotion, language, sense of self, and behavior. Epidemiological …
thinking, perception, emotion, language, sense of self, and behavior. Epidemiological …
Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia
Schizophrenia is a highly heritable, polygenic disorder. A growing list of common genetic
variants have been associated with schizophrenia; there is a clear need to understand the …
variants have been associated with schizophrenia; there is a clear need to understand the …
Beyond the mind—serum trace element levels in schizophrenic patients: A systematic review
The alterations in serum trace element levels are common phenomena observed in patients
with different psychiatric conditions such as schizophrenia, autism spectrum disorder, or …
with different psychiatric conditions such as schizophrenia, autism spectrum disorder, or …
Elevated serum MDA and depleted non-enzymatic antioxidants, macro-minerals and trace elements are associated with bipolar disorder
Genetic and neurobiological factors are considered to be the major causes of mood and
mental disorders. However, over the past few years, increased levels of serum …
mental disorders. However, over the past few years, increased levels of serum …
Genetically-informed patient selection for iPSC studies of complex diseases may aid in reducing cellular heterogeneity
SD Hoekstra, S Stringer, VM Heine… - Frontiers in cellular …, 2017 - frontiersin.org
Induced pluripotent stem cell (iPSC) technology is more and more used for the study of
genetically complex human disease but is challenged by variability, sample size and …
genetically complex human disease but is challenged by variability, sample size and …