The gut and the liver are characterized by mutual interactions between both organs, the
microbiome, diet and other environmental factors. The sum of these interactions is …

The gut microbiota not only constitutes intestinal microenvironment homeostasis and human
health but also exerts indispensable roles in the occurrence and progression of multiple liver …

The liver has a unique ability to regenerate,; however, in the setting of acute liver failure
(ALF), this regenerative capacity is often overwhelmed, leaving emergency liver …

While fecal microbiota transplantation (FMT) shows promise in treating human diseases,
oral capsule FMT is more accepted and accessible to patients. However, microbe selection …

Acetaminophen (APAP) overdose is the most common driver of drug-induced liver injury
(DILI) worldwide, and the gut microbiome plays a crucial role in this process. In this study …

For many years, it has been hypothesized that pathological changes to the gut microbiome
in critical illness is a driver of infections, organ dysfunction, and other adverse outcomes in …

Background: Drug overdose or chemical exposures are the main causes of acute liver injury
(ALI). Severe liver injury can develop into liver failure that is an important cause of liver …

The nucleotide-binding oligomerization and leucine-rich repeat receptor (NLR) protein
family consists of important immune sensors that form inflammasomes, a cytosolic multi …

Caspase-11 detection of intracellular lipopolysaccharide mediates non-canonical
pyroptosis, which could result in inflammatory damage and organ lesions in various …

The aryl hydrocarbon receptor (AHR) is a ubiquitously expressed ligand-activated
transcription factor with multifaceted physiological functions. In the immune system, AHR has …