All living organisms require nutrient minerals for growth and have developed mechanisms to
acquire, utilize, and store nutrient minerals effectively. In the aqueous cellular environment …

In their natural habitats, unicellular fungal microbes are exposed to a myriad of mechanical
cues such as shear forces from fluid flow, osmotic changes, and contact forces arising from …

Extracellular K+, Na+, and Ca 2+ ions all influence the resting membrane potential of the
neuron. However, the mechanisms by which extracellular Na+ and Ca 2+ regulate basal …

Chlorogenic acid (CGA) is a plant-derived compound with antifungal activity. However, the
antifungal mechanism of CGA remains not fully revealed. The antifungal effect of CGA …

The key players of calcium (Ca2+) homeostasis and Ca2+ signal generation, which are
Ca2+ channels, Ca2+/H+ antiporters, and Ca2+-ATPases, are present in all fungi. Their …

The bakers' yeast Saccharomyces cerevisiae utilizes a high affinity Ca 2+ influx system
(HACS) to survive assaults by mating pheromones, tunicamycin, and azole-class antifungal …

Sphingolipids are structural components of membranes, and sphingolipid metabolites serve
as signaling molecules. The first and rate-limiting step in sphingolipid synthesis is catalyzed …

Many infectious diseases disproportionately affect people in the develo** world.
Cryptococcal meningitis is one of the most common mycoses in HIV-AIDS patients, with the …

Four-domain voltage-gated cation channels (FVCCs) represent a large family of pseudo-
tetrameric ion channels which includes voltage-gated calcium (Cav) and sodium (Nav) …

Although the high affinity Ca2+ channel, Cch1, and its subunit Mid1 have been investigated
and evaluated in yeast and some of filamentous fungi, little is known about the function of …