What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
K Peng, BB Liang, W Liu, ZW Mao - Coordination Chemistry Reviews, 2021 - Elsevier
Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …
intensive works have been conducted to explore more platinum coordination complexes as …
Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: a focus on molecular pathways and possible therapeutic strategies
The failure of chemotherapy is a major challenge nowadays, and in order to ensure effective
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …
treatment of cancer patients, it is of great importance to reveal the molecular pathways and …
Aminoglycoside interactions and impacts on the eukaryotic ribosome
I Prokhorova, RB Altman… - Proceedings of the …, 2017 - National Acad Sciences
Aminoglycosides are chemically diverse, broad-spectrum antibiotics that target functional
centers within the bacterial ribosome to impact all four principle stages (initiation, elongation …
centers within the bacterial ribosome to impact all four principle stages (initiation, elongation …
How do cells cope with RNA damage and its consequences?
Similar to many other biological molecules, RNA is vulnerable to chemical insults from
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …
Cytotoxic platinum coordination compounds. DNA binding agents
V Brabec, O Hrabina, J Kasparkova - Coordination Chemistry Reviews, 2017 - Elsevier
Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …
disadvantages exist. In connection with attempts to circumvent these problems new platinum …
Oxidation and alkylation stresses activate ribosome-quality control
Oxidation and alkylation of nucleobases are known to disrupt their base-pairing properties
within RNA. It is, however, unclear whether organisms have evolved general mechanism (s) …
within RNA. It is, however, unclear whether organisms have evolved general mechanism (s) …
[HTML][HTML] ABCF ATPases involved in protein synthesis, ribosome assembly and antibiotic resistance: structural and functional diversification across the tree of life
Within the larger ABC superfamily of ATPases, ABCF family members eEF3 in
Saccharomyces cerevisiae and EttA in Escherichia coli have been found to function as …
Saccharomyces cerevisiae and EttA in Escherichia coli have been found to function as …
Unexpected therapeutic effects of cisplatin
Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both
carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and …
carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and …
The latest advances of cisplatin liposomal formulations: essentials for preparation and analysis
Introduction: Cisplatin has been indicated for several malignancies all over the world for
many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing …
many years. Increasing patient tolerance for high dose of chemotherapeutics and reducing …
Neuro-protective effect of rutin against Cisplatin-induced neurotoxic rat model
MM Almutairi, WA Alanazi, MA Alshammari… - … and alternative medicine, 2017 - Springer
Background Cisplatin is widely used chemotherapeutic agent for cancer treatment with
limited uses due to its neurotoxic side effect. The aim of this study was to determine the …
limited uses due to its neurotoxic side effect. The aim of this study was to determine the …