The role of gammaherpesviruses in cancer pathogenesis
Worldwide, one fifth of cancers in the population are associated with viral infections. Among
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
them, gammaherpesvirus, specifically HHV4 (EBV) and HHV8 (KSHV), are two oncogenic …
KSHV LANA—the master regulator of KSHV latency
Kaposi's sarcoma associated herpesvirus (KSHV), like other human herpes viruses,
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
establishes a biphasic life cycle referred to as dormant or latent, and productive or lytic …
The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA
AJ Barbera, JV Chodaparambil, B Kelley-Clarke… - Science, 2006 - science.org
Kaposi's sarcoma–associated herpesvirus (KSHV) latency-associated nuclear antigen
(LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal …
(LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal …
Molecular biology of KSHV lytic reactivation
Kaposi's sarcoma-associated herpesvirus (KSHV) primarily persists as a latent episome in
infected cells. During latent infection, only a limited number of viral genes are expressed that …
infected cells. During latent infection, only a limited number of viral genes are expressed that …
Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen inhibits lytic replication by targeting Rta: a potential mechanism for virus …
KE Lan, DA Kuppers, SC Verma… - Journal of virology, 2004 - Am Soc Microbiol
Like other herpesviruses, Kaposi's sarcoma-associated herpesvirus (KSHV, also designated
human herpesvirus 8) can establish a latent infection in the infected host. During latency a …
human herpesvirus 8) can establish a latent infection in the infected host. During latency a …
AIDS-related malignancies: emerging challenges in the era of highly active antiretroviral therapy
MC Cheung, L Pantanowitz, BJ Dezube - The oncologist, 2005 - academic.oup.com
Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the pathogenesis and clinical presentation of Kaposi's sarcoma, with a special …
Describe the pathogenesis and clinical presentation of Kaposi's sarcoma, with a special …
Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen interacts with bromodomain protein Brd4 on host mitotic chromosomes
The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus
(KSHV) is required for viral episome maintenance in host cells during latent infection. Two …
(KSHV) is required for viral episome maintenance in host cells during latent infection. Two …
A viral nuclear noncoding RNA binds re-localized poly (A) binding protein and is required for late KSHV gene expression
During the lytic phase of infection, the gamma herpesvirus K aposi's S arcoma-Associated H
erpes v irus (KSHV) expresses a highly abundant, 1.1 kb nuclear noncoding RNA of …
erpes v irus (KSHV) expresses a highly abundant, 1.1 kb nuclear noncoding RNA of …
G-quadruplex-interacting compounds alter latent DNA replication and episomal persistence of KSHV
Kaposi's sarcoma associated herpesvirus (KSHV) establishes life-long latent infection by
persisting as an extra-chromosomal episome in the infected cells and by maintaining its …
persisting as an extra-chromosomal episome in the infected cells and by maintaining its …
Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention
A Saha, R Kaul, M Murakami… - Cancer biology & …, 2010 - Taylor & Francis
Tumor viruses have provided relatively simple genetic systems, which can be manipulated
for understanding the molecular mechanisms of the cellular transformation process. A …
for understanding the molecular mechanisms of the cellular transformation process. A …