[HTML][HTML] Recent progress in drug delivery

C Li, J Wang, Y Wang, H Gao, G Wei, Y Huang… - … pharmaceutica sinica B, 2019 - Elsevier
Drug delivery systems (DDS) are defined as methods by which drugs are delivered to
desired tissues, organs, cells and subcellular organs for drug release and absorption …

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

TAS Aguirre, D Teijeiro-Osorio, M Rosa… - Advanced drug delivery …, 2016 - Elsevier
The development of oral dosage forms that allows absorption of therapeutic peptides to the
systemic circulation is one of the greatest challenges for the pharmaceutical industry …

A pH‐triggered self‐unpacking capsule containing zwitterionic hydrogel‐coated MOF nanoparticles for efficient oral exendin‐4 delivery

Y Zhou, Z Chen, D Zhao, D Li, C He… - Advanced …, 2021 - Wiley Online Library
Oral peptide or protein delivery is considered a revolutionary alternative to daily
subcutaneous injection; however, major challenges remain in terms of impediments of the …

[HTML][HTML] Advances in oral peptide drug nanoparticles for diabetes mellitus treatment

Y Li, W Zhang, R Zhao, X Zhang - Bioactive materials, 2022 - Elsevier
Peptide drugs play an important role in diabetes mellitus treatment. Oral administration of
peptide drugs is a promising strategy for diabetes mellitus because of its convenience and …

Chitosan: A promising therapeutic agent and effective drug delivery system in managing diabetes mellitus

S Sarkar, D Das, P Dutta, J Kalita, SB Wann… - Carbohydrate …, 2020 - Elsevier
Chitosan, a promising carbohydrate biopolymer is gaining scientific attention in a wide
range of biomedical applications due to its outstanding chemical and pharmacokinetic …

[HTML][HTML] Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins

Y Han, Z Gao, L Chen, L Kang, W Huang, M **… - … Pharmaceutica Sinica B, 2019 - Elsevier
In last few years, therapeutic peptides/proteins are rapidly growing in drug market
considering their higher efficiency and lower toxicity than chemical drugs. However, the …

An albumin-based theranostic nano-agent for dual-modal imaging guided photothermal therapy to inhibit lymphatic metastasis of cancer post surgery

Q Chen, C Liang, X Wang, J He, Y Li, Z Liu - Biomaterials, 2014 - Elsevier
A large variety of cancers are associated with a high incidence of lymph node metastasis,
which leads to a high risk of cancer death. Herein, we demonstrate that multimodal imaging …

Exendin‐4 analogs in insulinoma theranostics

TJP Jansen, SAM van Lith, M Boss… - Journal of Labelled …, 2019 - Wiley Online Library
Insulinomas are neuroendocrine tumors arising from the pancreatic beta cells. Currently,
surgical resection is the therapy of choice, and therefore, preoperative localization of …

Pharmacokinetic, pharmacodynamic and biodistribution following oral administration of nanocarriers containing peptide and protein drugs

BT Griffin, J Guo, E Presas, MD Donovan… - Advanced drug delivery …, 2016 - Elsevier
The influence of nanoparticle (NP) formulations on the pharmacokinetic, pharmacodynamic
and biodistribution profiles of peptide-and protein-like drugs following oral administration is …

PEG-PGA enveloped octaarginine-peptide nanocomplexes: an oral peptide delivery strategy

Z Niu, E Samaridou, E Jaumain, J Coëne… - Journal of controlled …, 2018 - Elsevier
The objective of this work was the development of a new drug nanocarrier intended to
overcome the barriers associated to the oral modality of administration and to assess its …