Cells are constantly exposed to a large variety of lipids. Traditionally, these molecules were
thought to serve as simple energy storing molecules. More recently it has been realized that …

Low levels of human medicines (pharmaceuticals) have been detected in many countries in
sewage treatment plant (STP) effluents, surface waters, seawaters, groundwater and some …

Peroxisome proliferator-activated receptor α is a potent regulator of systemic and cellular
metabolism and energy homeostasis, but it also suppresses various inflammatory reactions …

Nuclear receptors are major targets for drug discovery and have key roles in development
and homeostasis, as well as in many diseases such as obesity, diabetes and cancer. This …

Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …

Nuclear receptor pharmacology has, to a certain extent, led the way, compared with other
receptor systems, in the appreciation that ligands may exert very diverse pharmacology …

II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Nuclear receptors regulate metabolic pathways in response to changes in the environment
by appropriate alterations in gene expression of key metabolic enzymes. Here, a …

Recently we discovered a previously uncharacterized gene with the characteristics of a
membrane progestin receptor (mPR) in a fish model, spotted seatrout. Here, we report the …

Receptors for sex and adrenal steroid hormones are absent from fully sequenced
invertebrate genomes and have not been recovered from other invertebrates. Here we …