Sirtuins play an important role in signalling pathways associated with various metabolic
regulations. They possess mono-ADP-ribosyltransferase or deacylase activity like …

Mitochondria are dynamic organelles vital for energy production with now appreciated roles
in immune defense. During microbial infection, mitochondria serve as signaling hubs to …

Membrane contact sites (MCSs) link organelles to coordinate cellular functions across space
and time. Although viruses remodel organelles for their replication cycles, MCSs remain …

To effectively protect the host from viral infection while avoiding excessive
immunopathology, the innate immune response must be tightly controlled. However, the …

Mitochondrial dynamics homeostasis is sustained by continuous and balanced fission and
fusion, which are determinants of morphology, abundance, biogenesis and mitophagy of …

Global warming is changing the distribution of different pathogens around the globe, and
humans are more susceptible to new or re-emerging infections. The human response to …

Silent information regulators (Sirtuins) belong to the family of nicotinamide adenine
dinucleotide (NAD+)-dependent histone deacetylases (HDACs) that have diverse functions …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019, and the
resulting pandemic has already caused the death of over 6 million people. There are …

Human cytomegalovirus (HCMV) exploits host mitochondrial function to promote viral
replication. HCMV gene products have been described to directly interact and alter …

Highlights•Antiviral innate immunity is regulated by changes in cellular proteins.•These
include changes in abundance, localisation, interaction and PTMs.•Viral immune evasion …