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Acromegaly: pathogenesis, diagnosis, and management
M Fleseriu, F Langlois, DST Lim… - The Lancet Diabetes & …, 2022 - thelancet.com
Growth hormone-secreting pituitary adenomas that cause acromegaly arise as monoclonal
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …
expansions of differentiated somatotroph cells and are usually sporadic. They are almost …
A consensus on criteria for cure of acromegaly
Objective: The Acromegaly Consensus Group met in April 2009 to revisit the guidelines on
criteria for cure as defined in 2000. Participants: Participants included 74 neurosurgeons …
criteria for cure as defined in 2000. Participants: Participants included 74 neurosurgeons …
Acromegaly: an endocrine society clinical practice guideline
L Katznelson, ER Laws Jr, S Melmed… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for acromegaly. Participants:
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …
Acromegaly
S Melmed - New England Journal of Medicine, 2006 - Mass Medical Soc
Pituitary tumors account for about 15% of primary intracranial neoplasms. Proliferation of
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms …
pituitary cells, which secrete hormones, may result in a spectrum of endocrine symptoms …
Guidelines for acromegaly management: an update
" Objective: The Acromegaly Consensus Group reconvened in November 2007 to update
guidelines for acromegaly management. Participants: The meeting participants comprised …
guidelines for acromegaly management. Participants: The meeting participants comprised …
A consensus on the diagnosis and treatment of acromegaly complications
S Melmed, FF Casanueva, A Klibanski, MD Bronstein… - Pituitary, 2013 - Springer
Abstract In March 2011, the Acromegaly Consensus Group met to revise and update the
guidelines on the diagnosis and treatment of acromegaly complications. The meeting was …
guidelines on the diagnosis and treatment of acromegaly complications. The meeting was …
Resistance to somatostatin analogs in acromegaly
A Colao, RS Auriemma, G Lombardi… - Endocrine …, 2011 - academic.oup.com
Somatostatin analogs (SA) are widely used in acromegaly, either as first-line or adjuvant
treatment after surgery. First-line treatment with these drugs is generally used in the patients …
treatment after surgery. First-line treatment with these drugs is generally used in the patients …
Acromegaly
S Melmed - The pituitary, 2017 - Elsevier
Acromegaly is caused by excess growth hormone (GH) secretion emanating from a
somatotroph adenoma. High GH and Insulin-like growth factor-1 (IGF-1) levels lead to acral …
somatotroph adenoma. High GH and Insulin-like growth factor-1 (IGF-1) levels lead to acral …
Acromegaly
A Ben-Shlomo, S Melmed - Endocrinology and metabolism clinics of North …, 2008 - Elsevier
Acromegaly is a rare disease caused by growth hormone hypersecretion, mostly from a
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …
pituitary adenoma, driving insulin-like growth factor 1 overproduction. Manifestations include …
Primary treatment of acromegaly with octreotide LAR: a long-term (up to nine years) prospective study of its efficacy in the control of disease activity and tumor …
R Cozzi, M Montini, R Attanasio… - The Journal of …, 2006 - academic.oup.com
Context: Neurosurgery is regarded as the first-line treatment of acromegaly. Because of its
low cure rate in macro and invasive adenoma, the role of primary medical treatment is …
low cure rate in macro and invasive adenoma, the role of primary medical treatment is …