Blood protein extravasation through a disrupted blood–brain barrier and innate immune
activation are hallmarks of neurological diseases and emerging therapeutic targets …

Childhood adversity increases the risk of develo** psychosis, but the biological
mechanisms involved are unknown. Disaggregating early adverse experiences into core …

Inflammatory phenomena are found in many psychiatric disorders—notably, depression,
schizophrenia, and posttraumatic stress disorder. Inflammation has been linked to severity …

Parkinson's disease is highly heterogeneous across disease symptoms, clinical
manifestations and progression trajectories, hampering the identification of therapeutic …

Individuals at clinical high risk (CHR) for psychosis have been found to have altered
cytokine levels, but whether these changes are related to clinical outcomes remains unclear …

Alterations in the complement system have been reported in some people with psychotic
disorder, including in pre-psychotic individuals, suggesting that complement pathway …

Background Low-grade inflammation may occur in association with several mental disorders
of early adulthood, though associations with markers of chronic inflammation such as …

The biology underlying the connection between social relationships and health is largely
unknown. Here, leveraging data from 42,062 participants across 2,920 plasma proteins in …

Abstract Background and Hypothesis Treatment response to specific antipsychotic
medications is difficult to predict on clinical grounds alone. The current study hypothesizes …

This article describes the rationale, aims, and methodology of the Accelerating Medicines
Partnership® Schizophrenia (AMP® SCZ). This is the largest international collaboration to …