Background Thalassemia is an inherited hematological disorder categorized by a decrease
or absence of one or more of the globin chains synthesis. Beta‐thalassemia is caused by …

Inherited haemoglobin disorders, including thalassaemia and sickle-cell disease, are the
most common monogenic diseases worldwide. Several clinical forms of α-thalassaemia and …

Abstract β-Thalassemia is caused by reduced (β+) or absent (β 0) synthesis of the β-globin
chains of hemoglobin. Three clinical and hematological conditions of increasing severity are …

Over the past decade, our knowledge of the clinical diagnosis and management of
thalassemia has progressed extensively. In recent years, the most critical change in clinical …

Iron deficiency anemia (IDA) is the most prevalent and treatable form of anemia worldwide.
The clinical management of patients with IDA requires a comprehensive understanding of …

Iron Overload in Human Disease | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

Inherited anemias with ineffective erythropoiesis, such as β-thalassemia, manifest
inappropriately low hepcidin production and consequent excessive absorption of dietary …

Non-transfusion-dependent thalassemias include a variety of phenotypes that, unlike
patients with beta (β)-thalassemia major, do not require regular transfusion therapy for …

Thalassaemia is one of the most common genetic diseases worldwide, with at least 60 000
severely affected individuals born every year. Individuals originating from tropical and …

Beta-thalassaemia causes defective haemoglobin synthesis leading to ineffective
erythropoiesis, chronic haemolytic anaemia, and subsequent clinical complications. Blood …