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Alignment-free sequence analysis and applications
Genome and metagenome comparisons based on large amounts of next-generation
sequencing (NGS) data pose significant challenges for alignment-based approaches due to …
sequencing (NGS) data pose significant challenges for alignment-based approaches due to …
Benchmarking of alignment-free sequence comparison methods
Background Alignment-free (AF) sequence comparison is attracting persistent interest driven
by data-intensive applications. Hence, many AF procedures have been proposed in recent …
by data-intensive applications. Hence, many AF procedures have been proposed in recent …
To petabytes and beyond: recent advances in probabilistic and signal processing algorithms and their application to metagenomics
As computational biologists continue to be inundated by ever increasing amounts of
metagenomic data, the need for data analysis approaches that keep up with the pace of …
metagenomic data, the need for data analysis approaches that keep up with the pace of …
Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with …
JE Lemieux, W Huang, N Hill, T Cerar… - PLoS …, 2023 - journals.plos.org
Lyme disease is the most common vector-borne disease in North America and Europe. The
clinical manifestations of Lyme disease vary based on the genospecies of the infecting …
clinical manifestations of Lyme disease vary based on the genospecies of the infecting …
Squeakr: an exact and approximate k-mer counting system
Motivation k-mer-based algorithms have become increasingly popular in the processing of
high-throughput sequencing data. These algorithms span the gamut of the analysis pipeline …
high-throughput sequencing data. These algorithms span the gamut of the analysis pipeline …
Increased virulence of Puccinia coronata f. sp.avenae populations through allele frequency changes at multiple putative Avr loci
Pathogen populations are expected to evolve virulence traits in response to resistance
deployed in agricultural settings. However, few temporal datasets have been available to …
deployed in agricultural settings. However, few temporal datasets have been available to …
Do longer root hairs improve phosphorus uptake? Testing the hypothesis with transgenic Brachypodium distachyon lines overexpressing endogenous RSL genes
Mutants without root hairs show reduced inorganic orthophosphate (Pi) uptake and
compromised growth on soils when Pi availability is restricted. What is less clear is whether …
compromised growth on soils when Pi availability is restricted. What is less clear is whether …
Alignment-free sequence comparison: A systematic survey from a machine learning perspective
KS Bohnsack, M Kaden, J Abel… - IEEE/ACM Transactions …, 2022 - ieeexplore.ieee.org
The encounter of large amounts of biological sequence data generated during the last
decades and the algorithmic and hardware improvements have offered the possibility to …
decades and the algorithmic and hardware improvements have offered the possibility to …
[HTML][HTML] Information theory in computational biology: where we stand today
“A Mathematical Theory of Communication” was published in 1948 by Claude Shannon to
address the problems in the field of data compression and communication over (noisy) …
address the problems in the field of data compression and communication over (noisy) …
[HTML][HTML] Local Genomic Surveillance of Invasive Streptococcus pyogenes in Eastern North Carolina (ENC) in 2022–2023
W Huang, JE Markantonis, C Yin, JR Pozdol… - International Journal of …, 2024 - mdpi.com
The recent increase in Group A Streptococcus (GAS) incidences in several countries across
Europe and some areas of the Unites States (US) has raised concerns. To understand GAS …
Europe and some areas of the Unites States (US) has raised concerns. To understand GAS …