Alignment-free sequence analysis and applications

J Ren, X Bai, YY Lu, K Tang, Y Wang… - Annual Review of …, 2018 - annualreviews.org
Genome and metagenome comparisons based on large amounts of next-generation
sequencing (NGS) data pose significant challenges for alignment-based approaches due to …

Benchmarking of alignment-free sequence comparison methods

A Zielezinski, HZ Girgis, G Bernard, CA Leimeister… - Genome biology, 2019 - Springer
Background Alignment-free (AF) sequence comparison is attracting persistent interest driven
by data-intensive applications. Hence, many AF procedures have been proposed in recent …

To petabytes and beyond: recent advances in probabilistic and signal processing algorithms and their application to metagenomics

RAL Elworth, Q Wang, PK Kota… - Nucleic acids …, 2020 - academic.oup.com
As computational biologists continue to be inundated by ever increasing amounts of
metagenomic data, the need for data analysis approaches that keep up with the pace of …

Whole genome sequencing of human Borrelia burgdorferi isolates reveals linked blocks of accessory genome elements located on plasmids and associated with …

JE Lemieux, W Huang, N Hill, T Cerar… - PLoS …, 2023 - journals.plos.org
Lyme disease is the most common vector-borne disease in North America and Europe. The
clinical manifestations of Lyme disease vary based on the genospecies of the infecting …

Squeakr: an exact and approximate k-mer counting system

P Pandey, MA Bender, R Johnson, R Patro - Bioinformatics, 2018 - academic.oup.com
Motivation k-mer-based algorithms have become increasingly popular in the processing of
high-throughput sequencing data. These algorithms span the gamut of the analysis pipeline …

Increased virulence of Puccinia coronata f. sp.avenae populations through allele frequency changes at multiple putative Avr loci

ME Miller, ES Nazareno, SM Rottschaefer… - PLoS …, 2020 - journals.plos.org
Pathogen populations are expected to evolve virulence traits in response to resistance
deployed in agricultural settings. However, few temporal datasets have been available to …

Do longer root hairs improve phosphorus uptake? Testing the hypothesis with transgenic Brachypodium distachyon lines overexpressing endogenous RSL genes

C Zhang, RJ Simpson, CM Kim, N Warthmann… - New …, 2018 - Wiley Online Library
Mutants without root hairs show reduced inorganic orthophosphate (Pi) uptake and
compromised growth on soils when Pi availability is restricted. What is less clear is whether …

Alignment-free sequence comparison: A systematic survey from a machine learning perspective

KS Bohnsack, M Kaden, J Abel… - IEEE/ACM Transactions …, 2022 - ieeexplore.ieee.org
The encounter of large amounts of biological sequence data generated during the last
decades and the algorithmic and hardware improvements have offered the possibility to …

[HTML][HTML] Information theory in computational biology: where we stand today

P Chanda, E Costa, J Hu, S Sukumar, J Van Hemert… - Entropy, 2020 - mdpi.com
“A Mathematical Theory of Communication” was published in 1948 by Claude Shannon to
address the problems in the field of data compression and communication over (noisy) …

[HTML][HTML] Local Genomic Surveillance of Invasive Streptococcus pyogenes in Eastern North Carolina (ENC) in 2022–2023

W Huang, JE Markantonis, C Yin, JR Pozdol… - International Journal of …, 2024 - mdpi.com
The recent increase in Group A Streptococcus (GAS) incidences in several countries across
Europe and some areas of the Unites States (US) has raised concerns. To understand GAS …